CCND1

CCND1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2W96, 2W99, 2W9F, 2W9Z
Dynodwyr
Cyfenwau	CCND1, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
Dynodwyr allanol	OMIM: 168461 HomoloGene: 1334 GeneCards: CCND1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase activity • GO:0001106 transcription corepressor activity • transcription factor binding • histone deacetylase binding • kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • GO:0001948, GO:0016582 protein binding • enzyme binding • proline-rich region binding • protein kinase binding • cyclin-dependent protein serine/threonine kinase activity • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • cyclin-dependent protein kinase holoenzyme complex • bilen • bicellular tight junction • transcription repressor complex • intracellular anatomical structure • nucleoplasm • cnewyllyn cell Prosesau biolegol • cellular response to organic substance • mammary gland epithelial cell proliferation • positive regulation of mammary gland epithelial cell proliferation • response to estradiol • positive regulation of protein phosphorylation • Leydig cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1904578 response to organic cyclic compound • response to steroid hormone • response to corticosterone • negative regulation of Wnt signaling pathway • response to magnesium ion • response to glucocorticoid • re-entry into mitotic cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • Wnt signaling pathway • mammary gland alveolus development • response to organic substance • transcription, DNA-templated • response to vitamin E • regulation of cell cycle • response to iron ion • response to estrogen • response to calcium ion • Cellraniad • cellular response to DNA damage stimulus • endoplasmic reticulum unfolded protein response • protein phosphorylation • regulation of G1/S transition of mitotic cell cycle • liver regeneration • mitotic G1 DNA damage checkpoint signaling • animal organ regeneration • response to organonitrogen compound • positive regulation of cell population proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • canonical Wnt signaling pathway • response to UV-A • cell cycle • liver development • positive regulation of G2/M transition of mitotic cell cycle • lactation • response to ethanol • response to leptin • negative regulation of epithelial cell differentiation • fat cell differentiation • response to X-ray • positive regulation of cell cycle • transcription initiation from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • positive regulation of epithelial cell proliferation • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0007067 Mitosis • regulation of mitotic nuclear division • positive regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	595	n/a
Ensembl	ENSG00000110092	n/a
UniProt	P24385	n/a
RefSeq (mRNA)	NM_053056	n/a
RefSeq (protein)	NP_444284	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCND1 yw CCND1 a elwir hefyd yn Cyclin D1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCND1.

• BCL1
• PRAD1
• U21B31
• D11S287E

Llyfryddiaeth

• "Prognostic significance of cyclin D1 protein expression and gene amplification in invasive breast carcinoma. ". PLoS One. 2017. PMID 29140993.
• "The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis. ". Medicine (Baltimore). 2017. PMID 29049220.
• "Resveratrol Suppresses Growth and Migration of Myelodysplastic Cells by Inhibiting the Expression of Elevated Cyclin D1 (CCND1). ". DNA Cell Biol. 2017. PMID 29035583.
• "Bioinformatics prediction and experimental validation of microRNA-20a targeting Cyclin D1 in hepatocellular carcinoma. ". Tumour Biol. 2017. PMID 28378640.
• "Clinical significance of the phosphorylation of MAPK and protein expression of cyclin D1 in human osteosarcoma tissues.". Mol Med Rep. 2017. PMID 28260005.