CCL4

CCL4L1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L, 3TN2, 4RAL
Dynodwyr
Cyfenwau	CCL4L1, AT744.2, CCL4L, LAG-1, LAG1, SCYA4L, SCYA4L1, MIP-1-beta, SCYA4L2, C-C motif chemokine ligand 4 like 1
Dynodwyr allanol	OMIM: 603782 GeneCards: CCL4L1
Ontoleg y genyn Gweithrediad moleciwlaidd • chemokine activity • cytokine activity • GO:0001948, GO:0016582 protein binding • CCR chemokine receptor binding • CCR5 chemokine receptor binding • CCR1 chemokine receptor binding • identical protein binding Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • lymphocyte chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • G protein-coupled receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • chemotaxis • inflammatory response • cellular response to interleukin-1 • monocyte chemotaxis • neutrophil chemotaxis • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • regulation of signaling receptor activity • eosinophil chemotaxis • positive regulation of calcium-mediated signaling • positive regulation of natural killer cell chemotaxis • cell-cell signaling • response to virus • establishment or maintenance of cell polarity • cell adhesion • response to toxic substance • GO:0072468 signal transduction • positive regulation of calcium ion transport • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	388372	n/a
Ensembl	n/a	n/a
UniProt	Q8NHW4 P13236	n/a
RefSeq (mRNA)	NM_207007	n/a
RefSeq (protein)	NP_996890 NP_002975	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL4 yw CCL4 a elwir hefyd yn C-C motif chemokine ligand 4 like 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL4.

• ACT2
• G-26
• HC21
• LAG1
• LAG-1
• MIP1B
• SCYA2
• SCYA4
• MIP1B1
• AT744.1
• MIP-1-beta

Llyfryddiaeth

• "High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection. ". J Acquir Immune Defic Syndr. 2015. PMID 26115437.
• "MicroRNA-125b modulates inflammatory chemokine CCL4 expression in immune cells and its reduction causes CCL4 increase with age. ". Aging Cell. 2015. PMID 25620312.
• "Increased expression of CCL4/MIP-1β in CD8+ cells and CD4+ cells in sarcoidosis. ". Int J Immunopathol Pharmacol. 2014. PMID 25004830.
• "Procalcitonin and macrophage inflammatory protein-1 beta (MIP-1β) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis. ". Adv Med Sci. 2014. PMID 24797975.
• "The association between CCL2 polymorphisms and drug-resistant epilepsy in Chinese children.". Epileptic Disord. 2013. PMID 23996681.