CCL2

CCL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9
Dynodwyr
Cyfenwau	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
Dynodwyr allanol	OMIM: 158105 HomoloGene: 2245 GeneCards: CCL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • protein kinase activity • cytokine activity • GO:0001948, GO:0016582 protein binding • chemokine activity • CCR2 chemokine receptor binding • CCR chemokine receptor binding Cydrannau o'r gell • extracellular region • extracellular space • intracellular anatomical structure Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • viral genome replication • negative regulation of natural killer cell chemotaxis • protein phosphorylation • cell surface receptor signaling pathway • humoral immune response • angiogenesis • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • cellular homeostasis • cellular response to fibroblast growth factor stimulus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • inflammatory response • G protein-coupled receptor signaling pathway • monocyte chemotaxis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • GO:1904579 cellular response to organic cyclic compound • chemotaxis • cell adhesion • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of cell shape • lipopolysaccharide-mediated signaling pathway • receptor signaling pathway via JAK-STAT • response to bacterium • protein kinase B signaling • astrocyte cell migration • negative regulation of glial cell apoptotic process • PERK-mediated unfolded protein response • MAPK cascade • positive regulation of calcium ion import • cytoskeleton organization • GO:0072468 signal transduction • regulation of signaling receptor activity • neutrophil chemotaxis • helper T cell extravasation • macrophage chemotaxis • positive regulation of T cell activation • positive regulation of nitric-oxide synthase biosynthetic process • chemokine-mediated signaling pathway • cellular response to lipopolysaccharide • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • positive regulation of apoptotic cell clearance • cytokine-mediated signaling pathway • negative regulation of vascular endothelial cell proliferation • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • positive regulation of endothelial cell apoptotic process • eosinophil chemotaxis • lymphocyte chemotaxis • sensory perception of pain • positive regulation of synaptic transmission, glutamatergic • positive regulation of NMDA glutamate receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6347	n/a
Ensembl	ENSG00000108691	n/a
UniProt	P13500	n/a
RefSeq (mRNA)	NM_002982	n/a
RefSeq (protein)	NP_002973	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL2 yw CCL2 a elwir hefyd yn C-C motif chemokine ligand 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL2.

• HC11
• MCAF
• MCP1
• MCP-1
• SCYA2
• GDCF-2
• SMC-CF
• HSMCR30

Llyfryddiaeth

• "MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression. ". Tumour Biol. 2017. PMID 28618950.
• "Association study of MCP-1 promoter polymorphisms with the susceptibility and progression of sepsis. ". PLoS One. 2017. PMID 28472164.
• "Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study. ". Tohoku J Exp Med. 2017. PMID 28202856.
• "Elevated CCL2/MCP-1 Levels are Related to Disease Severity in Postmenopausal Osteoporotic Patients. ". Clin Lab. 2016. PMID 28164676.
• "Testosterone increases CCL-2 expression in visceral adipose tissue from obese women of reproductive age.". Mol Cell Endocrinol. 2017. PMID 28161330.