CBX5

CBX5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3FDT, 3I3C
Dynodwyr
Cyfenwau	CBX5, HEL25, HP1, HP1A, chromobox 5
Dynodwyr allanol	OMIM: 604478 HomoloGene: 7257 GeneCards: CBX5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • protein-macromolecule adaptor activity • chromatin binding • histone deacetylase binding • methylated histone binding • ribonucleoprotein complex binding • GO:0032403 protein-containing complex binding • identical protein binding Cydrannau o'r gell • kinetochore • cnewyllyn cell • nuclear envelope • pericentric heterochromatin • nucleolus • histone deacetylase complex • nucleoplasm • chromocenter • GO:0035328 heterochromatin • chromosome, centromeric region • histone methyltransferase complex • transcription repressor complex • Cromosom • PML body • GO:0009327 protein-containing complex • ribonucleoprotein complex • site of DNA damage Prosesau biolegol • blood coagulation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0022415 viral process • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of G0 to G1 transition • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23468	n/a
Ensembl	ENSG00000094916	n/a
UniProt	P45973	n/a
RefSeq (mRNA)	NM_012117 NM_001127321 NM_001127322	n/a
RefSeq (protein)	NP_001120793 NP_001120794 NP_036249	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBX5 yw CBX5 a elwir hefyd yn Chromobox 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBX5.

• HP1
• HP1A
• HEL25

Llyfryddiaeth

• "Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail. ". Sci Rep. 2016. PMID 26934956.
• "HP1 is involved in regulating the global impact of DNA methylation on alternative splicing. ". Cell Rep. 2015. PMID 25704815.
• "Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. ". Nature. 2017. PMID 28636604.
• "HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival. ". Biochem Biophys Res Commun. 2017. PMID 28623138.
• "SUMOylation of HP1α supports association with ncRNA to define responsiveness of breast cancer cells to chemotherapy.". Oncotarget. 2016. PMID 27107417.