CBX3

CBX3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3TZD, 2L11, 3DM1, 3KUP
Dynodwyr
Cyfenwau	CBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
Dynodwyr allanol	OMIM: 604477 HomoloGene: 40583 GeneCards: CBX3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • histone methyltransferase binding • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding Cydrannau o'r gell • nuclear envelope • spindle • nuclear inner membrane • chromatin • chromosome, centromeric region • cnewyllyn cell • condensed chromosome, centromeric region • nucleoplasm • site of DNA damage • senescence-associated heterochromatin focus Prosesau biolegol • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • transcription, DNA-templated • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of G0 to G1 transition • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • cellular response to DNA damage stimulus • cellular response to dexamethasone stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11335	n/a
Ensembl	ENSG00000122565	n/a
UniProt	Q13185	n/a
RefSeq (mRNA)	NM_007276 NM_016587	n/a
RefSeq (protein)	NP_009207 NP_057671	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBX3 yw CBX3 a elwir hefyd yn Chromobox 3 a Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p15.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBX3.

• HECH
• HP1-GAMMA
• HP1Hs-gamma

Llyfryddiaeth

• "Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ. ". J Mol Model. 2016. PMID 26680990.
• "Nucleosome compaction facilitates HP1γ binding to methylated H3K9. ". Nucleic Acids Res. 2015. PMID 26319017.
• "Overexpression of HP1γ is associated with poor prognosis in non-small cell lung cancer cell through promoting cell survival. ". Tumour Biol. 2014. PMID 24981246.
• "HP1γ expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy. ". BMC Cancer. 2013. PMID 23522301.
• "Heterochromatin protein 1γ overexpression in P19 embryonal carcinoma cells elicits spontaneous differentiation into the three germ layers.". Biochem Biophys Res Commun. 2013. PMID 23313480.