CBX2

CBX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D9U, 3H91, 5EPK
Dynodwyr
Cyfenwau	CBX2, CDCA6, M33, SRXY5, chromobox 2
Dynodwyr allanol	OMIM: 602770 HomoloGene: 7256 GeneCards: CBX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • methylated histone binding • chromatin binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • GO:0035328 heterochromatin • GO:0035327 euchromatin • PcG protein complex • PRC1 complex • cnewyllyn cell • nucleoplasm • Cromosom Prosesau biolegol • cell differentiation • development of primary sexual characteristics • sex differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	84733	n/a
Ensembl	ENSG00000173894	n/a
UniProt	Q14781	n/a
RefSeq (mRNA)	NM_005189 NM_032647	n/a
RefSeq (protein)	NP_005180 NP_116036	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBX2 yw CBX2 a elwir hefyd yn Chromobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBX2.

• M33
• CDCA6
• SRXY5

Llyfryddiaeth

• "Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role. ". Br J Cancer. 2014. PMID 25225902.
• "Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. ". PLoS One. 2008. PMID 19107218.
• "Phosphorylation of CBX2 controls its nucleosome-binding specificity. ". J Biochem. 2017. PMID 28992316.
• "Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer. ". Clin Epigenetics. 2016. PMID 26877821.
• "Genome-wide identification of CBX2 targets: insights in the human sex development network.". Mol Endocrinol. 2015. PMID 25569159.