CBX1

CBX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3Q6S, 2FMM, 3F2U
Dynodwyr
Cyfenwau	CBX1, CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta, chromobox 1
Dynodwyr allanol	OMIM: 604511 HomoloGene: 89116 GeneCards: CBX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • histone methyltransferase binding • enzyme binding • chromatin binding • GO:0001948, GO:0016582 protein binding • protein homodimerization activity • identical protein binding Cydrannau o'r gell • chromocenter • pericentric heterochromatin • chromatin • spindle • chromosome, centromeric region • male pronucleus • female pronucleus • nucleoplasm • cnewyllyn cell • site of DNA damage Prosesau biolegol • GO:0045996 negative regulation of transcription, DNA-templated • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10951	n/a
Ensembl	ENSG00000108468	n/a
UniProt	P83916	n/a
RefSeq (mRNA)	NM_006807 NM_001127228	n/a
RefSeq (protein)	NP_001120700 NP_006798	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBX1 yw CBX1 a elwir hefyd yn Chromobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBX1.

• CBX
• M31
• MOD1
• p25beta
• HP1-BETA
• HP1Hsbeta
• HP1Hs-beta

Llyfryddiaeth

• "Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1. ". J Biol Chem. 2017. PMID 28223359.
• "Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin. ". Nat Commun. 2016. PMID 27090491.
• "HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy. ". PLoS One. 2015. PMID 25769025.
• "Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. ". J Zhejiang Univ Sci B. 2014. PMID 24793759.
• "Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β.". FEBS Lett. 2014. PMID 24561199.