CBR1

CBR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WMA, 2PFG, 3BHI, 3BHJ, 3BHM, 4Z3D
Dynodwyr
Cyfenwau	CBR1, CBR, SDR21C1, hcarbonyl reductase 1, PG-9-KR
Dynodwyr allanol	OMIM: 114830 HomoloGene: 37524 GeneCards: CBR1
EC number	1.1.1.197
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • 15-hydroxyprostaglandin dehydrogenase (NADP+) activity • carbonyl reductase (NADPH) activity • prostaglandin-E2 9-reductase activity Cydrannau o'r gell • cytoplasm • extracellular vesicle • cytosol • extracellular exosome Prosesau biolegol • epithelial cell differentiation • vitamin K metabolic process • cyclooxygenase pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	873	n/a
Ensembl	ENSG00000159228	n/a
UniProt	P16152	n/a
RefSeq (mRNA)	NM_001757 NM_001286789	n/a
RefSeq (protein)	NP_001273718 NP_001748	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBR1 yw CBR1 a elwir hefyd yn Carbonyl reductase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBR1.

• CBR
• hCBR1
• SDR21C1

Llyfryddiaeth

• "Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. ". Biochem Pharmacol. 2017. PMID 28450226.
• "Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes. ". Chem Biol Interact. 2017. PMID 28274719.
• "Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation. ". Free Radic Biol Med. 2016. PMID 27562619.
• "Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione. ". J Struct Biol. 2015. PMID 26381805.
• "Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers.". Biol Pharm Bull. 2015. PMID 26328486.