CBLB

CBLB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AK5, 2BZ8, 2DO6, 2J6F, 2JNH, 2LDR, 2OOA, 2OOB, 3PFV, 3VGO, 3ZNI
Dynodwyr
Cyfenwau	CBLB, Cbl-b, RNF56, Nbla00127, Cbl proto-oncogene B
Dynodwyr allanol	OMIM: 604491 HomoloGene: 15856 GeneCards: CBLB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • phosphotyrosine residue binding • metal ion binding • GO:0001948, GO:0016582 protein binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity • SH3 domain binding • receptor tyrosine kinase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • zinc ion binding Cydrannau o'r gell • nucleoplasm • cytoplasm • cytosol • Cellbilen • membrane raft • cnewyllyn cell Prosesau biolegol • regulation of signaling • cell surface receptor signaling pathway • protein ubiquitination • NLS-bearing protein import into nucleus • GO:0072468 signal transduction • proteolysis • epidermal growth factor receptor signaling pathway • negative regulation of epidermal growth factor-activated receptor activity • regulation of platelet-derived growth factor receptor-alpha signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	868	n/a
Ensembl	ENSG00000114423	n/a
UniProt	Q13191	n/a
RefSeq (mRNA)	NM_170662 NM_001321786 NM_001321788 NM_001321789 NM_001321790 NM_001321791 NM_001321793 NM_001321794 NM_001321795 NM_001321796 NM_001321797 NM_001321798 NM_001321799 NM_001321806 NM_001321807 NM_001321808 NM_001321811 NM_001321813 NM_001321816 NM_001321820 NM_001321822 NM_004351	n/a
RefSeq (protein)	NP_001308715 NP_001308717 NP_001308718 NP_001308719 NP_001308720 NP_001308722 NP_001308723 NP_001308724 NP_001308725 NP_001308726 NP_001308727 NP_001308728 NP_001308735 NP_001308736 NP_001308737 NP_001308740 NP_001308742 NP_001308745 NP_001308749 NP_001308751 NP_733762	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBLB yw CBLB a elwir hefyd yn E3 ubiquitin-protein ligase CBL-B a Cbl proto-oncogene B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBLB.

• Cbl-b
• RNF56
• Nbla00127

Llyfryddiaeth

• "Lys63-polyubiquitination by the E3 ligase casitas B-lineage lymphoma-b (Cbl-b) modulates peripheral regulatory T cell tolerance in patients with systemic lupus erythematosus. ". Clin Exp Immunol. 2018. PMID 28940360.
• "E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. ". Neoplasia. 2017. PMID 28334634.
• "CBLB ubiquitin ligase: a major regulator of antifungal immunity. ". Nat Med. 2016. PMID 27490434.
• "Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin. ". Arch Biochem Biophys. 2016. PMID 26874193.
• "Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer.". Clin Lung Cancer. 2016. PMID 26732495.