CBFB

CBFB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CL3, 1E50, 1H9D, 4N9F
Dynodwyr
Cyfenwau	CBFB, PEBP2B, core-binding factor, beta subunit, core-binding factor beta subunit, core-binding factor subunit beta
Dynodwyr allanol	OMIM: 121360 HomoloGene: 11173 GeneCards: CBFB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 protein binding • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001104 transcription coregulator activity • sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • bilen • nucleoplasm • core-binding factor complex Prosesau biolegol • definitive hemopoiesis • myeloid cell differentiation • protein polyubiquitination • cell maturation • transcription by RNA polymerase II • ossification • osteoblast differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • lymphocyte differentiation • regulation of cytokine-mediated signaling pathway • regulation of Wnt signaling pathway • regulation of intracellular estrogen receptor signaling pathway • regulation of regulatory T cell differentiation • regulation of keratinocyte differentiation • regulation of myeloid cell differentiation • regulation of megakaryocyte differentiation • regulation of B cell receptor signaling pathway • regulation of hematopoietic stem cell differentiation • regulation of bicellular tight junction assembly • transcription initiation from RNA polymerase II promoter • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of CD4-positive, alpha-beta T cell differentiation • positive regulation of CD8-positive, alpha-beta T cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	865	n/a
Ensembl	ENSG00000067955	n/a
UniProt	Q13951	n/a
RefSeq (mRNA)	NM_001755 NM_022845 NM_001368707 NM_001368708 NM_001368709 NM_001368710	n/a
RefSeq (protein)	NP_001746 NP_074036 NP_001355636 NP_001355637 NP_001355638 NP_001355639	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBFB yw CBFB a elwir hefyd yn Core-binding factor beta subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBFB.

• PEBP2B

Llyfryddiaeth

• "D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia. ". Exp Hematol. 2017. PMID 28506695.
• "Core binding factor β (CBFβ) is retained in the midbody during cytokinesis. ". J Cell Physiol. 2014. PMID 24648201.
• "Association of core-binding factor β with the malignant phenotype of prostate and ovarian cancer cells. ". J Cell Physiol. 2010. PMID 20607802.
• "The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells. ". Mol Cancer. 2010. PMID 20591170.
• "A unique structural abnormality of chromosome 16 resulting in a CBF beta-MYH11 fusion transcript in a patient with acute myeloid leukemia, FAB M4.". Cancer Genet Cytogenet. 2000. PMID 10958941.