CBFA2T3

CBFA2T3
Dynodwyr
Cyfenwau	CBFA2T3, ETO2, MTG16, MTGR2, ZMYND4, RUNX1T3, CBFA2/RUNX1 translocation partner 3, CBFA2/RUNX1 partner transcriptional co-repressor 3
Dynodwyr allanol	OMIM: 603870 HomoloGene: 74543 GeneCards: CBFA2T3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948, GO:0016582 protein binding • metal ion binding • GO:0001106 transcription corepressor activity Cydrannau o'r gell • Golgi membrane • Golgi apparatus • nucleolus • bilen • cnewyllyn cell • nucleoplasm Prosesau biolegol • regulation of aerobic respiration • cell differentiation • cell population proliferation • negative regulation of glycolytic process • response to hypoxia • granulocyte differentiation • GO:0009373 regulation of transcription, DNA-templated • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • transcription, DNA-templated • negative regulation of cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	863	n/a
Ensembl	ENSG00000129993	n/a
UniProt	O75081	n/a
RefSeq (mRNA)	NM_005187 NM_175931	n/a
RefSeq (protein)	NP_005178 NP_787127	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBFA2T3 yw CBFA2T3 a elwir hefyd yn Protein CBFA2T3 a CBFA2/RUNX1 translocation partner 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBFA2T3.

• ETO2
• MTG16
• MTGR2
• ZMYND4
• RUNX1T3

Llyfryddiaeth

• "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. ". Cancer Res. 2002. PMID 12183414.
• "A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. ". Leuk Lymphoma. 2002. PMID 11999578.
• "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. ". Blood. 1998. PMID 9596646.
• "ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia. ". Cancer Cell. 2017. PMID 28292442.
• "Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene.". Turk J Haematol. 2016. PMID 27094503.