CAPN2

CAPN2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KFU, 1KFX, 2NQA
Dynodwyr
Cyfenwau	CAPN2, CANP2, CANPL2, CANPml, mCANP, calpain 2
Dynodwyr allanol	OMIM: 114230 HomoloGene: 1326 GeneCards: CAPN2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • cysteine-type peptidase activity; • metal ion binding; • cytoskeletal protein binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • hydrolase activity; • calcium-dependent cysteine-type endopeptidase activity; • enzyme binding;
Cydrannau o'r gell	• Golgi apparatus; • pseudopodium; • bilen; • focal adhesion; • perinuclear endoplasmic reticulum; • intracellular anatomical structure; • dendrite; • Reticwlwm endoplasmig; • cortical actin cytoskeleton; • membrane raft; • chromatin; • lysosome; • extracellular exosome; • cnewyllyn cell; • cytosol; • cytoplasm; • Cellbilen; • mitochondrial intermembrane space; • external side of plasma membrane; • cell projection; • neuronal cell body;
Prosesau biolegol	• response to hypoxia; • protein autoprocessing; • proteolysis; • cellular response to amino acid stimulus; • myoblast fusion; • proteolysis involved in cellular protein catabolic process; • regulation of cytoskeleton organization; • blastocyst development; • extracellular matrix disassembly; • female pregnancy; • positive regulation of cardiac muscle cell apoptotic process; • regulation of interleukin-6 production; • cellular response to interferon-beta; • response to hydrogen peroxide; • behavioral response to pain; • cellular response to lipopolysaccharide; • positive regulation of neuron death; • positive regulation of myoblast fusion; • positive regulation of phosphatidylcholine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	824
	n/a
	ENSG00000162909
	n/a
	P17655
	n/a
	NM_001146068; NM_001748
	n/a
	NP_001139540; NP_001739
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CAPN2 yw CAPN2 a elwir hefyd yn Calpain 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q41.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CAPN2.

CANP2
mCANP
CANPL2
CANPml

Llyfryddiaeth[golygu | golygu cod]

"Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway. ". Biomed Res Int. 2017. PMID 28280729.
"Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. ". Cell Death Dis. 2016. PMID 27077802.
"Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease. ". CNS Neurosci Ther. 2013. PMID 23889979.
"Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. ". Blood. 2013. PMID 23538341.
"Calpain system protein expression in basal-like and triple-negative invasive breast cancer.". Ann Oncol. 2012. PMID 22745213.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CAPN2 - Cronfa NCBI

[1]

[2]