CAPN1

CAPN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZCM, 2ARY
Dynodwyr
Cyfenwau	CAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
Dynodwyr allanol	OMIM: 114220 HomoloGene: 3800 GeneCards: CAPN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • metal ion binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • endopeptidase activity • calcium ion binding • calcium-dependent cysteine-type endopeptidase activity Cydrannau o'r gell • bilen • focal adhesion • intracellular anatomical structure • mitocondria • lysosome • extracellular exosome • cytosol • extracellular region • cytoplasm • Cellbilen • ficolin-1-rich granule lumen Prosesau biolegol • extracellular matrix disassembly • receptor catabolic process • positive regulation of cell population proliferation • regulation of macroautophagy • mammary gland involution • neutrophil degranulation • GO:0048552 regulation of catalytic activity • cornification • self proteolysis • proteolysis • regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	823	n/a
Ensembl	ENSG00000014216	n/a
UniProt	P07384	n/a
RefSeq (mRNA)	NM_001198868 NM_001198869 NM_005186	n/a
RefSeq (protein)	NP_001185797 NP_001185798 NP_005177	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CAPN1 yw CAPN1 a elwir hefyd yn Calpain-1 catalytic subunit a Calpain 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CAPN1.

• CANP
• muCL
• CANP1
• SPG76
• CANPL1
• muCANP

Llyfryddiaeth

• "Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. ". Acta Neuropathol Commun. 2016. PMID 27036949.
• "Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study. ". Histopathology. 2016. PMID 26496999.
• "Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis. ". PLoS One. 2015. PMID 26317226.
• "The structural basis of differential inhibition of human calpain by indole and phenyl α-mercaptoacrylic acids. ". J Struct Biol. 2014. PMID 25086406.
• "Proteolysis by endogenous calpain I leads to the activation of calcineurin in human heart.". Clin Lab. 2012. PMID 23289183.