C4A

C4A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HZF, 4FXG, 4FXK, 4XAM
Dynodwyr
Cyfenwau	C4A, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, complement component 4A (Rodgers blood group), complement C4A (Rodgers blood group)
Dynodwyr allanol	OMIM: 120810 HomoloGene: 36030 GeneCards: C4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase inhibitor activity • complement component C1q complex binding • serine-type endopeptidase activity Cydrannau o'r gell • extracellular region • Cellbilen • extracellular exosome • blood microparticle • cell projection • dendrite • cell junction • synapse • axon • neuronal cell body • extracellular space • endoplasmic reticulum lumen Prosesau biolegol • complement activation • inflammatory response • positive regulation of apoptotic cell clearance • regulation of complement activation • negative regulation of endopeptidase activity • complement activation, classical pathway • immune system process • innate immune response • proteolysis • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	720	n/a
Ensembl	ENSG00000244207 ENSG00000206340 ENSG00000244731 ENSG00000227746	n/a
UniProt	P0C0L4	n/a
RefSeq (mRNA)	NM_001252204 NM_007293	n/a
RefSeq (protein)	NP_001239133 NP_009224	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn C4A yw C4A a elwir hefyd yn Complement C4A (Rodgers blood group) (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn C4A.

• C4
• RG
• C4S
• CO4
• C4A2
• C4A3
• C4A4
• C4A6
• C4AD
• CPAMD2

Llyfryddiaeth

• "Complement factor C4 activation in patients with hereditary angioedema. ". Clin Biochem. 2017. PMID 28412283.
• "Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. ". Acta Crystallogr D Struct Biol. 2016. PMID 27599733.
• "Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD). ". J Neuroinflammation. 2016. PMID 27090374.
• "Effect of major histocompatibility complex haplotype matching by C4 and MICA genotyping on acute graft versus host disease in unrelated hematopoietic stem cell transplantation. ". Hum Immunol. 2016. PMID 26602146.
• "Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.". Inflamm Bowel Dis. 2016. PMID 26595553.