BPTF

BPTF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2F6J, 2F6N, 2FSA, 2FUI, 2FUU, 2RI7, 3QZS, 3QZT, 3QZV, 3UV2
Dynodwyr
Cyfenwau	BPTF, FAC1, FALZ, NURF301, bromodomain PHD finger transcription factor, NEDDFL
Dynodwyr allanol	OMIM: 601819 HomoloGene: 114397 GeneCards: BPTF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • ATP-dependent activity, acting on DNA • transcription factor binding • metal ion binding • GO:0001948, GO:0016582 protein binding • methylated histone binding Cydrannau o'r gell • cytoplasm • cell body • nucleoplasm • dendrite • NURF complex • perinuclear region of cytoplasm • neuron projection • extracellular exosome • cnewyllyn cell • Set1C/COMPASS complex Prosesau biolegol • chromatin remodeling • cellular response to nerve growth factor stimulus • endoderm development • GO:0009373 regulation of transcription, DNA-templated • embryonic placenta development • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • brain development • response to wounding • anterior/posterior pattern specification • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2186	n/a
Ensembl	ENSG00000171634	n/a
UniProt	Q12830	n/a
RefSeq (mRNA)	NM_004459 NM_182641	n/a
RefSeq (protein)	NP_004450 NP_872579	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BPTF yw BPTF a elwir hefyd yn Nucleosome-remodeling factor subunit BPTF (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BPTF.

• FAC1
• FALZ
• NEDDFL
• NURF301

Llyfryddiaeth

• "Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. ". Am J Hum Genet. 2017. PMID 28942966.
• "BPTF, a chromatin remodeling-related gene, exhibits frameshift mutations in gastric and colorectal cancers. ". APMIS. 2016. PMID 26899553.
• "BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas. ". Oncotarget. 2015. PMID 26418899.
• "The prognostic significance of bromodomain PHD-finger transcription factor in colorectal carcinoma and association with vimentin and E-cadherin. ". J Cancer Res Clin Oncol. 2015. PMID 25716692.
• "A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype.". PLoS One. 2010. PMID 20300178.