BNIP3

BNIP3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2J5D, 2KA1, 2KA2
Dynodwyr
Cyfenwau	BNIP3, NIP3, BCL2/adenovirus E1B 19kDa interacting protein 3, BCL2 interacting protein 3, HABON
Dynodwyr allanol	OMIM: 603293 HomoloGene: 2990 GeneCards: BNIP3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • identical protein binding • protein heterodimerization activity • GTPase binding Cydrannau o'r gell • cytoplasm • integral component of membrane • nuclear envelope • mitochondrial membranes • bilen • integral component of mitochondrial outer membrane • nucleoplasm • mitochondrial outer membrane • dendrite • Reticwlwm endoplasmig • mitocondria • mitochondrial envelope • cnewyllyn cell • GO:0097483, GO:0097481 postsynaptic density Prosesau biolegol • neuron apoptotic process • regulation of aerobic respiration • mitochondrial fragmentation involved in apoptotic process • positive regulation of mitochondrial fission • response to hypoxia • positive regulation of autophagy • regulation of mitochondrion organization • response to hyperoxia • positive regulation of cardiac muscle cell apoptotic process • marwolaeth celloedd • negative regulation of apoptotic process • positive regulation of programmed cell death • negative regulation of cell death • toxin transport • negative regulation of membrane potential • reactive oxygen species metabolic process • intrinsic apoptotic signaling pathway • positive regulation of macroautophagy • positive regulation of protein-containing complex disassembly • cellular response to mechanical stimulus • cellular response to cobalt ion • regulation of mitochondrial membrane permeability • autophagy of mitochondrion • defense response to virus • intrinsic apoptotic signaling pathway in response to hypoxia • brown fat cell differentiation • positive regulation of apoptotic process • positive regulation of release of cytochrome c from mitochondria • negative regulation of reactive oxygen species metabolic process • GO:0022415 viral process • negative regulation of mitochondrial fusion • granzyme-mediated apoptotic signaling pathway • mitochondrial outer membrane permeabilization • mitochondrial protein catabolic process • autophagic cell death • cellular response to hydrogen peroxide • GO:0097285 apoptotic process • cardiac muscle cell apoptotic process • negative regulation of mitochondrial membrane potential • positive regulation of necrotic cell death • cerebral cortex development • oligodendrocyte differentiation • positive regulation of mitochondrial calcium ion concentration • cellular response to hypoxia • negative regulation of mitochondrial membrane permeability involved in apoptotic process • positive regulation of autophagy of mitochondrion • response to bacterium Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	664	n/a
Ensembl	ENSG00000176171	n/a
UniProt	Q12983	n/a
RefSeq (mRNA)	NM_004052	n/a
RefSeq (protein)	NP_004043	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BNIP3 yw BNIP3 a elwir hefyd yn BCL2 interacting protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q26.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BNIP3.

• NIP3

Llyfryddiaeth

• "BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis. ". Cell Death Dis. 2017. PMID 28151469.
• "Armillaridin induces autophagy-associated cell death in human chronic myelogenous leukemia K562 cells. ". Tumour Biol. 2016. PMID 27592257.
• "Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin. ". Hum Mol Genet. 2015. PMID 26358776.
• "Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy. ". PLoS One. 2015. PMID 26102349.
• "Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells.". Oncol Rep. 2015. PMID 25891311.