BMP6

BMP6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2QCW, 2R52, 2R53
Dynodwyr
Cyfenwau	BMP6, VGR, VGR1, bone morphogenetic protein 6
Dynodwyr allanol	OMIM: 112266 HomoloGene: 1300 GeneCards: BMP6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • BMP receptor binding • protein heterodimerization activity • transforming growth factor beta receptor binding • growth factor activity Cydrannau o'r gell • cytoplasm • extracellular region • extracellular space • fesigl Prosesau biolegol • eye development • regulation of apoptotic process • skeletal system development • cell differentiation • cellular response to iron ion • male genitalia development • positive regulation of aldosterone secretion • positive regulation of endothelial cell differentiation • regulation of MAPK cascade • positive regulation of endothelial cell proliferation • SMAD protein signal transduction • positive regulation of aldosterone biosynthetic process • response to retinoic acid • ossification • kidney development • positive regulation of bone mineralization • positive regulation of epithelial cell proliferation • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to BMP stimulus • response to magnesium ion • response to glucocorticoid • GO:1901227 negative regulation of transcription by RNA polymerase II • endochondral ossification • response to activity • BMP signaling pathway • response to iron ion • positive regulation of lipopolysaccharide-mediated signaling pathway • multicellular organismal iron ion homeostasis • multicellular organism development • cellular response to mechanical stimulus • cartilage development • positive regulation of osteoblast differentiation • positive regulation of chondrocyte differentiation • osteoblast differentiation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of neuron differentiation • positive regulation of protein secretion • inflammatory response • type B pancreatic cell development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of SMAD protein signal transduction • cellular iron ion homeostasis • regulation of signaling receptor activity • positive regulation of cell population proliferation • cell development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	654	n/a
Ensembl	ENSG00000153162	n/a
UniProt	P22004	n/a
RefSeq (mRNA)	NM_001718	n/a
RefSeq (protein)	NP_001709	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BMP6 yw BMP6 a elwir hefyd yn Bone morphogenetic protein 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMP6.

• VGR
• VGR1

Llyfryddiaeth

• "Identification of new BMP6 pro-peptide mutations in patients with iron overload. ". Am J Hematol. 2017. PMID 28335084.
• "Bone morphogenetic protein 6-a possible new player in pathophysiology of heart failure. ". Clin Exp Pharmacol Physiol. 2016. PMID 27592865.
• "Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes. ". Biochem Biophys Res Commun. 2016. PMID 26855134.
• "BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells. ". Peptides. 2016. PMID 26779985.
• "Expression of BMP6 is associated with its methylation status in colorectal cancer tissue but lacks prognostic significance.". Asian Pac J Cancer Prev. 2014. PMID 25227796.