BMP2

BMP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
Dynodwyr
Cyfenwau	BMP2, BDA2, BMP2A, bone morphogenetic protein 2, SSFSC, SSFSC1
Dynodwyr allanol	OMIM: 112261 HomoloGene: 926 GeneCards: BMP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • cytokine activity • co-receptor binding • phosphatase activator activity • growth factor activity • BMP receptor binding • GO:0001948, GO:0016582 protein binding • NAD-retinol dehydrogenase activity • SMAD binding • protein heterodimerization activity • transforming growth factor beta receptor binding Cydrannau o'r gell • extracellular region • cell surface • BMP receptor complex • extracellular space • intracellular membrane-bounded organelle Prosesau biolegol • skeletal system development • positive regulation of Wnt signaling pathway by BMP signaling pathway • positive regulation of protein phosphorylation • mesenchyme development • negative regulation of cell cycle • odontogenesis of dentin-containing tooth • telencephalon regionalization • protein phosphorylation • atrioventricular valve morphogenesis • proteoglycan metabolic process • mesenchymal cell differentiation • pericardium development • positive regulation of ERK1 and ERK2 cascade • BMP signaling pathway involved in heart induction • animal organ morphogenesis • inner ear development • cardiocyte differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell population proliferation • positive regulation of p38MAPK cascade • pathway-restricted SMAD protein phosphorylation • cell fate commitment • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • ossification • in utero embryonic development • mesenchymal cell proliferation involved in ureteric bud development • regulation of odontogenesis of dentin-containing tooth • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • negative regulation of Wnt signaling pathway involved in heart development • cartilage development • bone mineralization involved in bone maturation • positive regulation of cartilage development • positive regulation of neuron differentiation • positive regulation of cell differentiation • thyroid-stimulating hormone-secreting cell differentiation • inflammatory response • positive regulation of fat cell differentiation • negative regulation of steroid biosynthetic process • positive regulation of MAPK cascade • Notch signaling pathway • bone mineralization • cell differentiation • chondrocyte differentiation • corticotropin hormone secreting cell differentiation • positive regulation of astrocyte differentiation • positive regulation of bone mineralization • GO:1904579 cellular response to organic cyclic compound • positive regulation of ossification • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of epithelial to mesenchymal transition • positive regulation of phosphatase activity • negative regulation of calcium-independent cell-cell adhesion • positive regulation of osteoblast differentiation • protein destabilization • embryonic heart tube anterior/posterior pattern specification • osteoblast differentiation • epithelial to mesenchymal transition • positive regulation of protein binding • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of odontogenesis • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • negative regulation of aldosterone biosynthetic process • positive regulation of osteoblast proliferation • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of cell migration • negative regulation of cortisol biosynthetic process • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to growth factor stimulus • cellular response to BMP stimulus • cardiac muscle tissue morphogenesis • endocardial cushion morphogenesis • multicellular organism development • negative regulation of cardiac muscle cell differentiation • positive regulation of apoptotic process • negative regulation of insulin-like growth factor receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cardiac epithelial to mesenchymal transition • positive regulation of pri-miRNA transcription by RNA polymerase II • GO:1901313 positive regulation of gene expression • BMP signaling pathway • cardiac muscle cell differentiation • cell development • regulation of signaling receptor activity • negative regulation of gene expression • response to bacterium • regulation of apoptotic process • regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	650	n/a
Ensembl	ENSG00000125845	n/a
UniProt	P12643	n/a
RefSeq (mRNA)	NM_001200	n/a
RefSeq (protein)	NP_001191	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BMP2 yw BMP2 a elwir hefyd yn Bone morphogenetic protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMP2.

• BDA2
• BMP2A

Llyfryddiaeth

• "A novel duplication downstream of BMP2 in a Chinese family with Brachydactyly type A2 (BDA2). ". Gene. 2018. PMID 29129813.
• "Two Variants of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) with Additional Protein Domains: Synthesis in an Escherichia coli Heterologous Expression System. ". Biochemistry (Mosc). 2017. PMID 28601071.
• "Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2. ". J Biol Chem. 2017. PMID 28584056.
• "Utilizing BMP-2 muteins for treatment of multiple myeloma. ". PLoS One. 2017. PMID 28489849.
• "Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective Analysis.". Biomed Res Int. 2017. PMID 28349058.