BMP1

BMP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EDG, 3EDH
Dynodwyr
Cyfenwau	BMP1, bone morphogenetic protein 1, OI13, PCOLC, PCP, PCP2, TLD
Dynodwyr allanol	OMIM: 112264 HomoloGene: 55955 GeneCards: BMP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • zinc ion binding • metal ion binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • metalloendopeptidase activity • growth factor activity • hydrolase activity • metallopeptidase activity • serine-type endopeptidase activity • cytokine activity • identical protein binding Cydrannau o'r gell • Golgi apparatus • extracellular region • fesigl • extracellular space Prosesau biolegol • skeletal system development • cell differentiation • ossification • extracellular matrix disassembly • proteolysis • multicellular organism development • cartilage development • positive regulation of cartilage development • cartilage condensation • high-density lipoprotein particle assembly • regulation of signaling receptor activity • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	649	n/a
Ensembl	ENSG00000168487	n/a
UniProt	P13497	n/a
RefSeq (mRNA)	NM_001199 NM_006128 NM_006129 NM_006130 NM_006131 NM_006132	n/a
RefSeq (protein)	NP_001190 NP_006120	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BMP1 yw BMP1 a elwir hefyd yn BMP1 protein a Bone morphogenetic protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMP1.

• PCP
• TLD
• OI13
• PCP2
• PCOLC

Llyfryddiaeth

• "Phenotypic variability in patients with osteogenesis imperfecta caused by BMP1 mutations. ". Am J Med Genet A. 2016. PMID 27576954.
• "Characterization of post-translational modifications in full-length human BMP-1 confirms the presence of a rare vicinal disulfide linkage in the catalytic domain and highlights novel features of the EGF domain. ". J Proteomics. 2016. PMID 26944735.
• "CCN2/CTGF expression via cellular uptake of BMP-1 is associated with reparative dentinogenesis. ". Oral Dis. 2015. PMID 25944709.
• "BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling. ". Matrix Biol. 2015. PMID 25701650.
• "Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta.". Hum Mutat. 2015. PMID 25402547.