BMI1

BMI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H0D, 3RPG, 4R8P
Dynodwyr
Cyfenwau	BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
Dynodwyr allanol	OMIM: 164831 HomoloGene: 136787 GeneCards: BMI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • promoter-specific chromatin binding • RING-like zinc finger domain binding • metal ion binding • GO:0001948, GO:0016582 protein binding • zinc ion binding Cydrannau o'r gell • cytoplasm • ubiquitin ligase complex • nucleoplasm • PRC1 complex • PcG protein complex • cnewyllyn cell • cytosol • nuclear body Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • positive regulation of fibroblast proliferation • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • segment specification • negative regulation of gene expression, epigenetic • positive regulation of ubiquitin-protein transferase activity • regulation of gene expression • histone H2A-K119 monoubiquitination • negative regulation of G0 to G1 transition • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • hemopoiesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	648	n/a
Ensembl	ENSG00000168283	n/a
UniProt	P35226 Q5T8Z6	n/a
RefSeq (mRNA)	NM_005180	n/a
RefSeq (protein)	NP_001190991 NP_005171	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BMI1 yw BMI1 a elwir hefyd yn BMI1 proto-oncogene, polycomb ring finger a Polycomb complex protein BMI-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p12.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMI1.

• PCGF4
• RNF51
• FLVI2/BMI1
• flvi-2/bmi-1

Llyfryddiaeth

• "Clinical Significance of Bmi1 Expression in Inflammatory Bowel Disease. ". Oncology. 2017. PMID 29258116.
• "O-GlcNAcylation modulates Bmi-1 protein stability and potential oncogenic function in prostate cancer. ". Oncogene. 2017. PMID 28714959.
• "Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer. ". Medicine (Baltimore). 2017. PMID 28658153.
• "Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma. ". Anticancer Res. 2017. PMID 28373461.
• "Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy.". Oncol Rep. 2017. PMID 28260023.