BIRC5

BIRC5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E31, 1F3H, 1XOX, 2QFA, 2RAW, 2RAX, 3UEC, 3UED, 3UEE, 3UEF, 3UEG, 3UEH, 3UEI, 3UIG, 3UIH, 3UII, 3UIJ, 3UIK, 4A0I, 4A0J, 4A0N
Dynodwyr
Cyfenwau	BIRC5, API4, EPR-1, baculoviral IAP repeat containing 5
Dynodwyr allanol	OMIM: 603352 HomoloGene: 37450 GeneCards: BIRC5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • cobalt ion binding • chaperone binding • protein homodimerization activity • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • tubulin binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • GO:0001948, GO:0016582 protein binding • identical protein binding • protein heterodimerization activity • enzyme binding • microtubule binding • zinc ion binding • cysteine-type endopeptidase inhibitor activity Cydrannau o'r gell • cytosol • spindle • Cromosom • nucleoplasm • chromosome passenger complex • nuclear chromosome • interphase microtubule organizing center • spindle microtubule • centriole • cytoplasmic microtubule • Cytosgerbwd • microtubule • kinetochore • midbody • cytoplasm • chromosome, centromeric region • cnewyllyn cell Prosesau biolegol • negative regulation of peptidase activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0009373 regulation of transcription, DNA-templated • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • establishment of chromosome localization • chromosome segregation • positive regulation of mitotic cell cycle • positive regulation of exit from mitosis • transcription, DNA-templated • Cellraniad • protein phosphorylation • mitotic spindle assembly • regulation of signal transduction • G2/M transition of mitotic cell cycle • positive regulation of cell population proliferation • protein-containing complex localization • cell cycle • GO:0045996 negative regulation of transcription, DNA-templated • GO:0097285 apoptotic process • regulation of apoptotic process • negative regulation of apoptotic process • regulation of mitotic cell cycle • GO:0007067 Mitosis • clyw • mitotic cytokinesis • mitotic spindle assembly checkpoint signaling • cytokine-mediated signaling pathway • protein ubiquitination • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	332	n/a
Ensembl	ENSG00000089685	n/a
UniProt	O15392	n/a
RefSeq (mRNA)	NM_001012270 NM_001012271 NM_001168	n/a
RefSeq (protein)	NP_001012270 NP_001012271 NP_001159	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BIRC5 yw BIRC5 a elwir hefyd yn Baculoviral IAP repeat containing 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BIRC5.

• API4
• EPR-1

Llyfryddiaeth

• "Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients. ". PLoS One. 2017. PMID 28981528.
• "The anti-apoptotic protein survivin can improve the prognostication of meningioma patients. ". PLoS One. 2017. PMID 28953948.
• "Polymorphisms of survivin -31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. ". J BUON. 2017. PMID 28365965.
• "Un-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinoma. ". Bratisl Lek Listy. 2017. PMID 28319412.
• "Clinicalpathological and prognostic significance of survivin expression in renal cell carcinoma: a meta-analysis.". Oncotarget. 2017. PMID 28178644.