BIRC2

BIRC2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7
Dynodwyr
Cyfenwau	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, baculoviral IAP repeat containing 2
Dynodwyr allanol	OMIM: 601712 HomoloGene: 900 GeneCards: BIRC2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • metal ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • GO:0001948, GO:0016582 protein binding • transferase activity • ubiquitin binding • chaperone binding • FBXO family protein binding • zinc ion binding • GO:0001105 transcription coactivator activity • GO:0050372 ubiquitin-protein transferase activity • identical protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • cytosol • XY body • membrane raft • CD40 receptor complex • cytoplasmic side of plasma membrane • cnewyllyn cell • cytoplasm • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • regulation of nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of protein K63-linked ubiquitination • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • regulation of innate immune response • GO:1904578 response to organic cyclic compound • negative regulation of ripoptosome assembly involved in necroptotic process • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • placenta development • regulation of cysteine-type endopeptidase activity • regulation of RIG-I signaling pathway • regulation of tumor necrosis factor-mediated signaling pathway • tumor necrosis factor-mediated signaling pathway • GO:1904489 regulation of reactive oxygen species metabolic process • transcription, DNA-templated • positive regulation of protein monoubiquitination • mitotic spindle assembly • cell surface receptor signaling pathway • NIK/NF-kappaB signaling • regulation of cell population proliferation • response to organonitrogen compound • positive regulation of protein K48-linked ubiquitination • response to cAMP • response to ethanol • I-kappaB kinase/NF-kappaB signaling • proteasome-mediated ubiquitin-dependent protein catabolic process • GO:0060554, GO:0060555 necroptosis • GO:0097285 apoptotic process • protein deubiquitination • cellular response to tumor necrosis factor • regulation of NIK/NF-kappaB signaling • positive regulation of protein polyubiquitination • negative regulation of necroptotic process • protein polyubiquitination • regulation of toll-like receptor signaling pathway • negative regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of cell differentiation • regulation of inflammatory response • regulation of cell cycle • regulation of necroptotic process • protein heterooligomerization • positive regulation of nucleic acid-templated transcription • MyD88-independent toll-like receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • positive regulation of protein ubiquitination • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	329	n/a
Ensembl	ENSG00000110330	n/a
UniProt	Q13490	n/a
RefSeq (mRNA)	NM_001256166 NM_001166 NM_001256163	n/a
RefSeq (protein)	NP_001157 NP_001243092 NP_001243095	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BIRC2 yw BIRC2 a elwir hefyd yn Baculoviral IAP repeat-containing protein 2 a Baculoviral IAP repeat containing 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q22.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BIRC2.

• API1
• MIHB
• HIAP2
• RNF48
• cIAP1
• Hiap-2
• c-IAP1

Llyfryddiaeth

• "shRNA Depletion of cIAP1 Sensitizes Human Ovarian Cancer Cells to Anticancer Agent-Induced Apoptosis. ". Oncol Res. 2014. PMID 26168135.
• "Dynamic activation of apoptosis: conformational ensembles of cIAP1 are linked to a spring-loaded mechanism. ". Nat Struct Mol Biol. 2014. PMID 25469840.
• "Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. ". Vitam Horm. 2014. PMID 24559922.
• "The cellular inhibitor of apoptosis protein-2 is a possible target of novel treatment for endometriosis. ". Am J Reprod Immunol. 2014. PMID 24382102.
• "BIRC2 amplification in squamous cell carcinomas of the uterine cervix.". Virchows Arch. 2012. PMID 22733500.