BIN1

BIN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MUZ, 1MV0, 1MV3, 2FIC, 2RMY, 2RND, 5I22
Dynodwyr
Cyfenwau	BIN1, AMPH2, AMPHL, SH3P9, bridging integrator 1, CNM2
Dynodwyr allanol	OMIM: 601248 HomoloGene: 113707 GeneCards: BIN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • RNA polymerase binding • identical protein binding • tau protein binding • actin filament binding • protease binding • phospholipid binding • clathrin binding • chaperone binding Cydrannau o'r gell • cytoplasm • bilen • I band • T-tubule • lipid tube • node of Ranvier • axon • Z disc • actin cytoskeleton • axon initial segment • cnewyllyn cell • nuclear envelope • cytosol • endosome • Cytosgerbwd • Cellbilen • synaptic vesicle • sarcolemma • synapse Prosesau biolegol • regulation of endocytosis • regulation of neuron differentiation • cell differentiation • endocytosis • positive regulation of astrocyte differentiation • multicellular organism development • muscle cell differentiation • positive regulation of apoptotic process • lipid tube assembly • cell population proliferation • GO:0022415 viral process • nucleus localization • nucleus organization • membrane organization • cytoskeleton organization • endosome to lysosome transport • positive regulation of actin filament polymerization • T-tubule organization • regulation of heart rate by cardiac conduction • negative regulation of potassium ion transmembrane transport • negative regulation of amyloid-beta formation • negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • negative regulation of ventricular cardiac muscle cell action potential • negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	274	n/a
Ensembl	ENSG00000136717	n/a
UniProt	O00499	n/a
RefSeq (mRNA)	NM_004305 NM_139343 NM_139344 NM_139345 NM_139346 NM_139347 NM_139348 NM_139349 NM_139350 NM_139351 NM_001320632 NM_001320633 NM_001320634 NM_001320640 NM_001320641 NM_001320642	n/a
RefSeq (protein)	NP_001307561 NP_001307562 NP_001307563 NP_001307569 NP_001307570 NP_001307571 NP_004296 NP_647593 NP_647594 NP_647595 NP_647596 NP_647597 NP_647598 NP_647599 NP_647600 NP_647601 NP_647601.1 NP_001307561.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BIN1 yw BIN1 a elwir hefyd yn Bridging integrator 1, isoform CRA_g , Bridging integrator 1, isoform CRA_j a Bridging integrator 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BIN1.

• CNM2
• AMPH2
• AMPHL
• SH3P9

Llyfryddiaeth

• "The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations. ". Clin Chim Acta. 2017. PMID 28302384.
• "The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. ". Mol Neurodegener. 2016. PMID 27538496.
• "Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. ". J Neuropathol Exp Neurol. 2016. PMID 27346750.
• "Potential contribution of the Alzheimer's disease risk locus BIN1 to episodic memory performance in cognitively normal Type 2 diabetes elderly. ". Eur Neuropsychopharmacol. 2016. PMID 26947052.
• "The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson disease.". J Neurol. 2015. PMID 26233692.