BECN1

BECN1
Strwythurau PDB Human UniProt search: K7ER46 PDBe K7ER46 RCSB Rhestr o ddynodwyr PDB 2P1L, 2PON, 3DVU, 4DDP, 4MI8
Dynodwyr
Cyfenwau	BECN1, ATG6, VPS30, beclin1, beclin 1
Dynodwyr allanol	OMIM: 604378 HomoloGene: 2794 GeneCards: BECN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol 3-kinase binding • GO:0001948, GO:0016582 protein binding • GTPase binding • ubiquitin protein ligase binding • protein kinase binding • protein homodimerization activity Cydrannau o'r gell • endosome membrane • cytoplasm • mitochondrial membranes • trans-Golgi network • Golgi apparatus • cytosol • cnewyllyn cell • autophagosome • phagophore assembly site • bilen • dendrite • Reticwlwm endoplasmig • phosphatidylinositol 3-kinase complex, class III • endoplasmic reticulum membrane • phosphatidylinositol 3-kinase complex, class III, type II • GO:0016023 cytoplasmic vesicle • endosome • extrinsic component of membrane • phosphatidylinositol 3-kinase complex, class III, type I • phagocytic vesicle • mitocondria • GO:0009327 protein-containing complex Prosesau biolegol • negative regulation of cell population proliferation • response to hypoxia • cellular response to aluminum ion • response to vitamin E • lysosome organization • cell cycle • positive regulation of phosphatidylinositol 3-kinase signaling • cellular response to glucose starvation • cellular defense response • cytokinesis • cellular response to epidermal growth factor stimulus • Cellraniad • receptor catabolic process • autophagy of nucleus • cellular response to nitrogen starvation • GO:0022415 viral process • late endosome to vacuole transport • GO:0097285 apoptotic process • cytoplasm to vacuole transport by the Cvt pathway • endocytosis • engulfment of apoptotic cell • positive regulation of attachment of mitotic spindle microtubules to kinetochore • amyloid-beta metabolic process • neuron development • defense response to virus • response to other organism • mitotic metaphase plate congression • GO:0048552 regulation of catalytic activity • negative regulation of reactive oxygen species metabolic process • regulation of cytokinesis • negative regulation of apoptotic process • negative regulation of cell death • autophagosome assembly • macroautophagy • GO:0010260 heneiddio • response to iron(II) ion • response to lead ion • protein deubiquitination • response to nutrient levels • cellular response to amino acid starvation • cellular response to hydrogen peroxide • cellular response to copper ion • negative regulation of lysosome organization • positive regulation of autophagosome assembly • autophagy of mitochondrion • mitophagy • autophagy • positive regulation of autophagy • response to mitochondrial depolarisation • early endosome to late endosome transport • negative regulation of autophagy • positive regulation of cardiac muscle hypertrophy • negative regulation of autophagosome assembly • positive regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8678	n/a
Ensembl	ENSG00000126581	n/a
UniProt	Q14457	n/a
RefSeq (mRNA)	NM_001313998 NM_001313999 NM_001314000 NM_003766	n/a
RefSeq (protein)	NP_001300927 NP_001300928 NP_001300929 NP_003757	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn 'BECN1 yw BECN1 a elwir hefyd yn Beclin-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BECN1.

• ATG6
• VPS30
• beclin1

Llyfryddiaeth

• "Intensified Beclin-1 Mediated by Low Expression of Mir-30a-5p Promotes Chemoresistance in Human Small Cell Lung Cancer. ". Cell Physiol Biochem. 2017. PMID 28977798.
• "Structural transitions in conserved, ordered Beclin 1 domains essential to regulating autophagy. ". J Biol Chem. 2017. PMID 28798234.
• "Caspase mediated beclin-1 dependent autophagy tuning activity and apoptosis promotion by surface modified hausmannite nanoparticle. ". J Biomed Mater Res A. 2017. PMID 28076888.
• "Expression, modulation, and clinical correlates of the autophagy protein Beclin-1 in esophageal adenocarcinoma. ". Mol Carcinog. 2016. PMID 27696537.
• "RelA-Mediated BECN1 Expression Is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation.". PLoS One. 2016. PMID 27632526.