BAK1

BAK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI
Dynodwyr
Cyfenwau	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1
Dynodwyr allanol	OMIM: 600516 HomoloGene: 917 GeneCards: BAK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transmembrane transporter binding • metal ion binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein homodimerization activity • molecular function • heat shock protein binding • protein heterodimerization activity • chaperone binding • BH domain binding Cydrannau o'r gell • integral component of membrane • cytosol • bilen • mitochondrial membranes • integral component of mitochondrial outer membrane • intracellular anatomical structure • Reticwlwm endoplasmig • mitocondria • pore complex • mitochondrial outer membrane • BAK complex Prosesau biolegol • GO:1990613 mitochondrial fusion • leukocyte homeostasis • regulation of apoptotic process • positive regulation of endoplasmic reticulum unfolded protein response • establishment or maintenance of transmembrane electrochemical gradient • limb morphogenesis • positive regulation of calcium ion transport into cytosol • GO:1904578 response to organic cyclic compound • B cell apoptotic process • regulation of protein heterodimerization activity • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • vagina development • homeostasis of number of cells • cellular response to UV • myeloid cell homeostasis • GO:0010260 heneiddio • post-embryonic camera-type eye morphogenesis • B cell homeostasis • thymocyte apoptotic process • endoplasmic reticulum calcium ion homeostasis • negative regulation of gene expression • regulation of cell cycle • regulation of mitochondrial membrane potential • positive regulation of IRE1-mediated unfolded protein response • blood vessel remodeling • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • brain development • response to fungus • regulation of mitochondrial membrane permeability • cellular response to mechanical stimulus • fibroblast apoptotic process • activation of cysteine-type endopeptidase activity • apoptotic process involved in blood vessel morphogenesis • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • animal organ regeneration • negative regulation of peptidyl-serine phosphorylation • positive regulation of proteolysis • positive regulation of release of cytochrome c from mitochondria • apoptotic signaling pathway • negative regulation of endoplasmic reticulum calcium ion concentration • cell population proliferation • response to ethanol • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to gamma radiation • regulation of protein homodimerization activity • response to UV-C • response to hydrogen peroxide • endocrine pancreas development • release of cytochrome c from mitochondria • B cell negative selection • negative regulation of cell population proliferation • response to mycotoxin • positive regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • GO:0097285 apoptotic process • Unfolded Protein Response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	578	n/a
Ensembl	ENSG00000030110	n/a
UniProt	Q16611	n/a
RefSeq (mRNA)	NM_001188	n/a
RefSeq (protein)	NP_001179	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BAK1 yw BAK1 a elwir hefyd yn BCL2 antagonist/killer 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BAK1.

• BAK
• CDN1
• BCL2L7
• BAK-LIKE

Llyfryddiaeth

• "Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever. ". BMC Med Genet. 2016. PMID 27401010.
• "E6 proteins from low-risk human papillomavirus types 6 and 11 are able to protect keratinocytes from apoptosis via Bak degradation. ". J Gen Virol. 2016. PMID 26743580.
• "Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells. ". Genes Dev. 2015. PMID 26494789.
• "BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer. ". Gastric Cancer. 2016. PMID 26486506.
• "High Bak Expression Is Associated with a Favorable Prognosis in Breast Cancer and Sensitizes Breast Cancer Cells to Paclitaxel.". PLoS One. 2015. PMID 26406239.