BAG6

BAG6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WX9, 4DWF, 4EEW, 4WWR, 4X86, 2N9P
Dynodwyr
Cyfenwau	BAG6, BAG-6, BAT3, D6S52E, G3, HLA-B associated transcript 3, BCL2 associated athanogene 6, BAG cochaperone 6
Dynodwyr allanol	OMIM: 142590 HomoloGene: 3409 GeneCards: BAG6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ribosome binding • misfolded protein binding • Hsp70 protein binding • polyubiquitin modification-dependent protein binding • proteasome binding • GO:0001948, GO:0016582 protein binding • ubiquitin-specific protease binding • ubiquitin protein ligase binding • signaling receptor binding • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • intracellular membrane-bounded organelle • nucleoplasm • BAT3 complex • cnewyllyn cell • extracellular region • extracellular exosome Prosesau biolegol • regulation of apoptotic process • negative regulation of proteolysis • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cell differentiation • ubiquitin-dependent protein catabolic process • kidney development • embryo development • lung development • immune system process • positive regulation of ERAD pathway • protein stabilization • negative regulation of apoptotic process • internal peptidyl-lysine acetylation • brain development • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • regulation of cell population proliferation • synaptonemal complex assembly • spermatogenesis • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • protein localization to cytosolic proteasome complex involved in ERAD pathway • maintenance of unfolded protein involved in ERAD pathway • tail-anchored membrane protein insertion into ER membrane • ER-associated misfolded protein catabolic process • immune response-activating cell surface receptor signaling pathway • GO:0097285 apoptotic process • natural killer cell activation • proteasomal protein catabolic process • ubiquitin-dependent ERAD pathway • endoplasmic reticulum stress-induced pre-emptive quality control • GO:0015915 transport • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of embryonic development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7917	n/a
Ensembl	ENSG00000204463 ENSG00000228760 ENSG00000234651 ENSG00000229524 ENSG00000096155 ENSG00000227761 ENSG00000233348	n/a
UniProt	P46379	n/a
RefSeq (mRNA)	NM_001098534 NM_001199697 NM_001199698 NM_004639 NM_080702 NM_080703	n/a
RefSeq (protein)	NP_001092004 NP_001186626 NP_001186627 NP_542433 NP_542434	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BAG6 yw BAG6 a elwir hefyd yn BCL2 associated athanogene 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BAG6.

• G3
• BAT3
• BAG-6
• D6S52E

Llyfryddiaeth

• "A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localization. ". PLoS One. 2012. PMID 22558287.
• "Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis. ". Biochem Biophys Res Commun. 2001. PMID 11587531.
• "Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis. ". Med Sci Monit. 2014. PMID 25430685.
• "BAT3 rs1052486 and rs3117582 polymorphisms are associated with lung cancer risk: a meta-analysis. ". Tumour Biol. 2014. PMID 24989925.
• "Involvement of Bag6 and the TRC pathway in proteasome assembly.". Nat Commun. 2013. PMID 23900548.