BACE2

BACE2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EWY, 3ZKG, 3ZKI, 3ZKM, 3ZKN, 3ZKQ, 3ZKS, 3ZKX, 3ZL7, 3ZLQ, 4BEL, 4BFB
Dynodwyr
Cyfenwau	BACE2, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP, beta-site APP-cleaving enzyme 2, beta-secretase 2
Dynodwyr allanol	OMIM: 605668 HomoloGene: 22696 GeneCards: BACE2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • amyloid-beta binding • hydrolase activity • aspartic-type endopeptidase activity Cydrannau o'r gell • integral component of membrane • cell surface • endosome • Golgi apparatus • Reticwlwm endoplasmig • bilen • Cellbilen • cytoplasm • trans-Golgi network • dense core granule Prosesau biolegol • peptide hormone processing • GO:0044257 protein catabolic process • amyloid-beta metabolic process • negative regulation of amyloid precursor protein biosynthetic process • proteolysis • membrane protein ectodomain proteolysis • astrocyte activation • glucose homeostasis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	25825	n/a
Ensembl	ENSG00000182240	n/a
UniProt	Q9Y5Z0	n/a
RefSeq (mRNA)	NM_138992 NM_012105 NM_138991	n/a
RefSeq (protein)	NP_036237 NP_620476 NP_620477	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BACE2 yw BACE2 a elwir hefyd yn Beta-site APP-cleaving enzyme 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.2-q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BACE2.

• ASP1
• BAE2
• DRAP
• AEPLC
• ALP56
• ASP21
• CDA13
• CEAP1

Llyfryddiaeth

• "Identification of BACE2 as an avid ß-amyloid-degrading protease. ". Mol Neurodegener. 2012. PMID 22986058.
• "BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells. ". Am J Physiol Endocrinol Metab. 2010. PMID 20943756.
• "Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2. ". Genes Brain Behav. 2010. PMID 19840121.
• "The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain. ". Biochem Soc Trans. 2007. PMID 17511655.
• "BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.". FASEB J. 2006. PMID 16816112.