AXL

AXL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C5D, 4RA0
Dynodwyr
Cyfenwau	AXL, AZF, AZFA, SP3, AZF1, ARK, JTK11, Tyro7, UFO, AXL receptor tyrosine kinase
Dynodwyr allanol	OMIM: 109135 HomoloGene: 7583 GeneCards: AXL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein kinase activity • transferase activity • virus receptor activity • kinase activity • protein heterodimerization activity • ATP binding • phosphatidylserine binding • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • phosphatidylinositol 3-kinase binding • myosin heavy chain binding • protein tyrosine kinase activity • Wnt-protein binding Cydrannau o'r gell • extracellular exosome • integral component of membrane • host cell surface • integral component of plasma membrane • cell surface • bilen • intracellular anatomical structure • Cellbilen • extracellular space • receptor complex Prosesau biolegol • protein kinase B signaling • positive regulation of natural killer cell differentiation • apoptotic cell clearance • negative regulation of lymphocyte activation • spermatogenesis • negative regulation of apoptotic process • GO:0072468 signal transduction • natural killer cell differentiation • negative regulation of interferon-gamma production • cellular response to lipopolysaccharide • secretion by cell • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • erythrocyte homeostasis • negative regulation of tumor necrosis factor production • positive regulation of protein kinase B signaling • GO:0022415 viral process • positive regulation of cytokine-mediated signaling pathway • cellular response to interferon-alpha • forebrain cell migration • viral entry into host cell • negative regulation of dendritic cell apoptotic process • protein phosphorylation • cellular response to extracellular stimulus • enzyme linked receptor protein signaling pathway • positive regulation of pinocytosis • GO:1904089 negative regulation of neuron apoptotic process • vagina development • ovulation cycle • innate immune response • blood vessel remodeling • cell maturation • dendritic cell differentiation • platelet activation • cell differentiation • immune system process • inflammatory response • neuron migration • phosphorylation • cellular response to hydrogen peroxide • animal organ regeneration • ffagocytosis • peptidyl-tyrosine phosphorylation • GO:0032697 negative regulation of cytokine production • neutrophil clearance • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • Wnt signaling pathway • cell migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	558	n/a
Ensembl	ENSG00000167601	n/a
UniProt	P30530	n/a
RefSeq (mRNA)	NM_001278599 NM_001699 NM_021913	n/a
RefSeq (protein)	NP_001265528 NP_001690 NP_068713	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AXL yw AXL a elwir hefyd yn AXL receptor tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AXL.

• ARK
• UFO
• JTK11
• Tyro7

Llyfryddiaeth

• "Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells. ". Anticancer Res. 2018. PMID 29277784.
• "The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. ". PLoS One. 2017. PMID 28727830.
• "The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase. ". J Biol Chem. 2017. PMID 28724631.
• "Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. ". Lab Invest. 2017. PMID 28553934.
• "Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses.". Cell Rep. 2017. PMID 28076778.