ATP2A1

ATP2A1
Dynodwyr
Cyfenwau	ATP2A1, ATP2A, SERCA1, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Dynodwyr allanol	OMIM: 108730 HomoloGene: 7635 GeneCards: ATP2A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • calcium ion binding • protein homodimerization activity • metal ion binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • ATP binding • P-type calcium transporter activity • ATPase activity • GO:0036442 P-type proton-exporting transporter activity Cydrannau o'r gell • integral component of membrane • endoplasmic reticulum membrane • bilen • I band • calcium channel complex • H zone • sarcoplasmic reticulum • platelet dense tubular network membrane • Reticwlwm endoplasmig • sarcoplasmic reticulum membrane • perinuclear region of cytoplasm • endoplasmic reticulum-Golgi intermediate compartment • mitocondria Prosesau biolegol • regulation of cardiac conduction • positive regulation of fast-twitch skeletal muscle fiber contraction • negative regulation of striated muscle contraction • calcium ion import • positive regulation of endoplasmic reticulum calcium ion concentration • cludo ïon • response to endoplasmic reticulum stress • maintenance of mitochondrion location • cludo transmembrane rhwng ïonau • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • regulation of striated muscle contraction • apoptotic mitochondrial changes • relaxation of skeletal muscle • negative regulation of endoplasmic reticulum calcium ion concentration • positive regulation of mitochondrial calcium ion concentration • calcium ion transport • calcium ion transmembrane transport • cellular calcium ion homeostasis • proton transmembrane transport • calcium ion import into sarcoplasmic reticulum • positive regulation of cardiac muscle cell contraction • positive regulation of ATPase-coupled calcium transmembrane transporter activity • positive regulation of calcium ion import into sarcoplasmic reticulum Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	487	n/a
Ensembl	ENSG00000196296	n/a
UniProt	O14983	n/a
RefSeq (mRNA)	NM_173201 NM_001286075 NM_004320	n/a
RefSeq (protein)	NP_001273004 NP_004311 NP_775293	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATP2A1 yw ATP2A1 a elwir hefyd yn Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ac ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATP2A1.

• ATP2A
• SERCA1

Llyfryddiaeth

• "Sphingosine inhibits the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) activity. ". Biochem Biophys Res Commun. 2016. PMID 27033604.
• "SERCA1 protein expression in muscle of patients with Brody disease and Brody syndrome and in cultured human muscle fibers. ". Mol Genet Metab. 2013. PMID 23911890.
• "Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway. ". Biochem Biophys Res Commun. 2012. PMID 22609207.
• "Use of glycerol-containing media to study the intrinsic fluorescence properties of detergent-solubilized native or expressed SERCA1a. ". Biochemistry. 2008. PMID 18947188.
• "Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1.". Hum Mol Genet. 2007. PMID 17728322.