ATIC

ATIC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P4R, 1PKX, 1PL0
Dynodwyr
Cyfenwau	ATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Dynodwyr allanol	OMIM: 601731 HomoloGene: 2983 GeneCards: ATIC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein homodimerization activity • IMP cyclohydrolase activity • catalytic activity • phosphoribosylaminoimidazolecarboxamide formyltransferase activity • hydrolase activity • cadherin binding Cydrannau o'r gell • cytosol • bilen • mitocondria • extracellular exosome • Cellbilen Prosesau biolegol • purine nucleotide biosynthetic process • dihydrofolate metabolic process • 'de novo' IMP biosynthetic process • brainstem development • ribonucleotide metabolic process • cerebellum development • nucleoside metabolic process • tetrahydrofolate biosynthetic process • animal organ regeneration • response to inorganic substance • cerebral cortex development • purine ribonucleoside monophosphate biosynthetic process • metabolaeth • nucleobase-containing compound metabolic process • cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	471	n/a
Ensembl	ENSG00000138363	n/a
UniProt	P31939	n/a
RefSeq (mRNA)	NM_004044	n/a
RefSeq (protein)	NP_004035	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATIC yw ATIC a elwir hefyd yn 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q35.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATIC.

• PURH
• AICAR
• AICARFT
• IMPCHASE
• HEL-S-70p

Llyfryddiaeth

• "ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma. ". J Pediatr Hematol Oncol. 2017. PMID 28267080.
• "Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. ". Rheumatol Int. 2016. PMID 27379764.
• "ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis. ". Pharmacogenomics. 2016. PMID 26799664.
• "The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. ". J Biol Chem. 2002. PMID 11948179.
• "Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.". J Biol Chem. 2001. PMID 11096114.