ASPH

ASPH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	5APA
Dynodwyr
Cyfenwau	ASPH, AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin, aspartate beta-hydroxylase
Dynodwyr allanol	OMIM: 600582 HomoloGene: 20910 GeneCards: ASPH
EC number	1.14.11.16
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transmembrane transporter binding; • dioxygenase activity; • structural molecule activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • electron transfer activity; • oxidoreductase activity; • structural constituent of muscle; • calcium ion binding; • peptidyl-aspartic acid 3-dioxygenase activity;
Cydrannau o'r gell	• integral component of membrane; • calcium channel complex; • bilen; • Cellbilen; • cortical endoplasmic reticulum; • junctional sarcoplasmic reticulum membrane; • sarcoplasmic reticulum; • integral component of endoplasmic reticulum membrane; • sarcoplasmic reticulum membrane; • sarcoplasmic reticulum lumen; • endoplasmic reticulum membrane; • Reticwlwm endoplasmig; • cytoplasm;
Prosesau biolegol	• cellular response to calcium ion; • positive regulation of intracellular protein transport; • regulation of ryanodine-sensitive calcium-release channel activity; • regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; • response to ATP; • regulation of cardiac conduction; • muscle contraction; • positive regulation of calcium ion transport into cytosol; • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; • peptidyl-amino acid modification; • detection of calcium ion; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of ryanodine-sensitive calcium-release channel activity; • cludo transmembrane rhwng ïonau; • activation of cysteine-type endopeptidase activity; • calcium ion transmembrane transport; • positive regulation of proteolysis; • regulation of cell communication by electrical coupling; • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • activation of store-operated calcium channel activity; • pattern specification process; • negative regulation of cell population proliferation; • regulation of protein stability; • limb morphogenesis; • peptidyl-aspartic acid hydroxylation; • roof of mouth development; • face morphogenesis; • regulation of protein depolymerization; • electron transport chain;
	Sources:Amigo / QuickGO
Orthologau
	444
	n/a
	ENSG00000198363
	n/a
	Q12797
	n/a
NM_001164750; NM_001164751; NM_001164752; NM_001164753; NM_001164754;
	NM_001164755; NM_001164756; NM_004318; NM_020164; NM_032466; NM_032467; NM_032468
	n/a
NP_001158222; NP_001158223; NP_001158224; NP_001158225; NP_001158226;
	NP_001158227; NP_001158228; NP_004309; NP_064549; NP_115855; NP_115856; NP_115857
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ASPH yw ASPH a elwir hefyd yn Aspartate beta-hydroxylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q12.3.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ASPH.

AAH
BAH
HAAH
JCTN
FDLAB
junctin
CASQ2BP1

Llyfryddiaeth[golygu | golygu cod]

"Evaluation of HAAH/humbug quantitative detection in the diagnosis of hepatocellular carcinoma. ". Oncol Rep. 2015. PMID 25394783.
"siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth. ". Pathol Res Pract. 2011. PMID 21862239.
"Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinoma. ". Hum Pathol. 2009. PMID 19200576.
"[Expression of aspartyl-(asparaginyl) beta-hydroxylase in villi in patients with missed abortion]. ". Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009. PMID 19197126.
"Overexpression of humbug promotes malignant progression in human gastric cancer cells.". Oncol Rep. 2008. PMID 18288418.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] ASPH - Cronfa NCBI

[1]

[2]