ARRB1

ARRB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IV8
Dynodwyr
Cyfenwau	ARRB1, ARB1, ARR1, Arrestin beta 1
Dynodwyr allanol	OMIM: 107940 HomoloGene: 2981 GeneCards: ARRB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • histone acetyltransferase activity • GO:0048551 enzyme inhibitor activity • insulin-like growth factor receptor binding • transcription factor binding • mitogen-activated protein kinase kinase binding • clathrin adaptor activity • protein phosphorylated amino acid binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • GO:0001948, GO:0016582 protein binding • AP-2 adaptor complex binding • alpha-1B adrenergic receptor binding • V2 vasopressin receptor binding • phosphoprotein binding • angiotensin receptor binding • ubiquitin protein ligase binding • arrestin family protein binding • signaling receptor binding • enzyme binding • estrogen receptor binding • alpha-1A adrenergic receptor binding • follicle-stimulating hormone receptor binding • transmembrane transporter binding • clathrin binding • G protein-coupled receptor binding Cydrannau o'r gell • cytoplasm • cytosol • postsynaptic membrane • bilen • cnewyllyn cell • cell projection • dendritic spine • heterotrimeric G-protein complex • chromatin • Cellbilen • intracellular anatomical structure • nucleoplasm • clathrin-coated pit • pseudopodium • GO:0097483, GO:0097481 postsynaptic density • Golgi membrane • lysosomal membrane • basolateral plasma membrane • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • nuclear body • endosome Prosesau biolegol • positive regulation of Rho protein signal transduction • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor internalization • transcription by RNA polymerase II • stress fiber assembly • follicle-stimulating hormone signaling pathway • platelet activation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0034259 negative regulation of GTPase activity • positive regulation of ERK1 and ERK2 cascade • positive regulation of insulin secretion involved in cellular response to glucose stimulus • proteasome-mediated ubiquitin-dependent protein catabolic process • phototransduction • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • negative regulation of interleukin-8 production • protein ubiquitination • protein transport • GO:0033128 negative regulation of protein phosphorylation • positive regulation of smooth muscle cell apoptotic process • positive regulation of histone H4 acetylation • positive regulation of protein binding • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein ubiquitination • G protein-coupled receptor internalization • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • endocytosis • negative regulation of interleukin-6 production • positive regulation of histone acetylation • negative regulation of protein ubiquitination • negative regulation of ERK1 and ERK2 cascade • negative regulation of signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • GO:0097285 apoptotic process • membrane organization • regulation of apoptotic process • ubiquitin-dependent protein catabolic process • negative regulation of Notch signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of protein phosphorylation • positive regulation of cell population proliferation • negative regulation of apoptotic process • GO:1904089 negative regulation of neuron apoptotic process • histone acetylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	408	n/a
Ensembl	ENSG00000137486	n/a
UniProt	P49407	n/a
RefSeq (mRNA)	NM_004041 NM_020251	n/a
RefSeq (protein)	NP_004032 NP_064647	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARRB1 yw ARRB1 a elwir hefyd yn Arrestin beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.4.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARRB1.

• ARB1
• ARR1

Llyfryddiaeth

• "ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response. ". Oncol Rep. 2017. PMID 28035404.
• "Apoptosis in human myelodysplastic syndrome CD34+ cells is modulated by the upregulation of TLRs and histone H4 acetylation via a β-arrestin 1 dependent mechanism. ". Exp Cell Res. 2016. PMID 26708616.
• "β-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor. ". Int J Clin Exp Pathol. 2015. PMID 26097560.
• "Association of ARRB1 polymorphisms with the risk of major depressive disorder and with treatment response to mirtazapine. ". J Psychopharmacol. 2015. PMID 25294870.
• "β-Arrestin1 promotes the progression of chronic myeloid leukaemia by regulating BCR/ABL H4 acetylation.". Br J Cancer. 2014. PMID 24937675.