ARNT

ARNT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
Dynodwyr
Cyfenwau	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
Dynodwyr allanol	OMIM: 126110 HomoloGene: 1261 GeneCards: ARNT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • aryl hydrocarbon receptor binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein homodimerization activity • sequence-specific double-stranded DNA binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity Cydrannau o'r gell • cytoplasm • transcription regulator complex • nucleoplasm • RNA polymerase II transcription regulator complex • cnewyllyn cell • nuclear body Prosesau biolegol • positive regulation of vascular endothelial growth factor receptor signaling pathway • cell differentiation • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • positive regulation of erythrocyte differentiation • embryonic placenta development • mRNA transcription by RNA polymerase II • positive regulation of protein sumoylation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of vascular endothelial growth factor production • positive regulation of glycolytic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of hormone biosynthetic process • xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	405	n/a
Ensembl	ENSG00000143437	n/a
UniProt	P27540	n/a
RefSeq (mRNA)	NM_001197325 NM_001286035 NM_001286036 NM_001668 NM_178426 NM_178427 NM_001350224 NM_001350225 NM_001350226	n/a
RefSeq (protein)	NP_001184254 NP_001272964 NP_001272965 NP_001659 NP_848514 NP_001337153 NP_001337154 NP_001337155	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARNT yw ARNT a elwir hefyd yn Aryl hydrocarbon receptor nuclear translocator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARNT.

• HIF1B
• TANGO
• bHLHe2
• HIF1BETA
• HIF-1beta
• HIF1-beta
• HIF-1-beta

Llyfryddiaeth

• "The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. ". Radiat Oncol. 2015. PMID 26572229.
• "LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118. ". Oncotarget. 2015. PMID 26388611.
• "Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). ". J Clin Endocrinol Metab. 2015. PMID 25343232.
• "Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia. ". PLoS One. 2014. PMID 25068796.
• "An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death.". PLoS One. 2014. PMID 24921657.