ARHGEF12

ARHGEF12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TXD, 1X86, 2OMJ, 2OS6
Dynodwyr
Cyfenwau	ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12
Dynodwyr allanol	OMIM: 604763 HomoloGene: 9088 GeneCards: ARHGEF12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • G protein-coupled receptor binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • guanyl-nucleotide exchange factor activity Cydrannau o'r gell • cytoplasm • cytosol • extracellular exosome • bilen Prosesau biolegol • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • regulation of Rho protein signal transduction • GO:0007243 intracellular signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of apoptotic process • G protein-coupled receptor signaling pathway • regulation of molecular function • Rho protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23365	n/a
Ensembl	ENSG00000196914	n/a
UniProt	Q9NZN5	n/a
RefSeq (mRNA)	NM_001198665 NM_001301084 NM_015313	n/a
RefSeq (protein)	NP_001185594 NP_001288013 NP_056128	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGEF12 yw ARHGEF12 a elwir hefyd yn Rho guanine nucleotide exchange factor 12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGEF12.

• LARG
• PRO2792

Llyfryddiaeth

• "LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways. ". Cell Signal. 2012. PMID 22100544.
• "Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF. ". J Biol Chem. 2010. PMID 20018869.
• "Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage. ". J Cell Biol. 2016. PMID 27298323.
• "ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure. ". Hum Mol Genet. 2015. PMID 25637523.
• "Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.". Mol Biol Cell. 2013. PMID 23885121.