ARHGAP1

ARHGAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Dynodwyr
Cyfenwau	ARHGAP1, CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP, Rho GTPase activating protein 1
Dynodwyr allanol	OMIM: 602732 HomoloGene: 20909 GeneCards: ARHGAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • GO:0001948, GO:0016582 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • cadherin binding Cydrannau o'r gell • cytosol • extracellular exosome • cytoplasm • endosome membrane • perinuclear region of cytoplasm • sorting endosome • bilen • integral component of membrane Prosesau biolegol • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • GO:0072468 signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • small GTPase mediated signal transduction • positive regulation of signal transduction • transferrin transport • iron ion import across cell outer membrane • negative regulation of endocytic recycling • endosomal transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	392	n/a
Ensembl	ENSG00000175220	n/a
UniProt	Q07960	n/a
RefSeq (mRNA)	NM_004308	n/a
RefSeq (protein)	NP_004299	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGAP1 yw ARHGAP1 a elwir hefyd yn Rho GTPase-activating protein 1 a Rho GTPase activating protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGAP1.

• RHOGAP
• RHOGAP1
• CDC42GAP
• p50rhoGAP

Llyfryddiaeth

• "Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells. ". J Cell Sci. 2016. PMID 27311480.
• "ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells. ". Biochim Biophys Acta. 2013. PMID 23200924.
• "Nm23-H1 regulates the proliferation and differentiation of the human chronic myeloid leukemia K562 cell line: a functional proteomics study. ". Life Sci. 2009. PMID 19302816.
• "Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation. ". Angiogenesis. 2008. PMID 18060510.
• "Gene expression profiling of metastatic brain cancer.". Oncol Rep. 2007. PMID 17611651.