APPL1

APPL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EJ8, 2ELA, 2ELB, 2Q12, 2Q13, 2Z0N, 2Z0O, 5C5B
Dynodwyr
Cyfenwau	APPL1, APPL, DIP13alpha, MODY14, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Dynodwyr allanol	OMIM: 604299 HomoloGene: 32143 GeneCards: APPL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase B binding • GO:0001948, GO:0016582 protein binding • identical protein binding • phosphatidylserine binding • phosphatidylinositol binding • protein homodimerization activity • GO:0032403 protein-containing complex binding • beta-tubulin binding Cydrannau o'r gell • cytoplasm • NuRD complex • cytosol • endosome • early endosome membrane • bilen • vesicle membrane • endosome membrane • extracellular exosome • cnewyllyn cell • early endosome • ruffle • Cellbilen • GO:0016023 cytoplasmic vesicle • early phagosome • macropinosome • intracellular vesicle • cell projection • phagocytic vesicle Prosesau biolegol • regulation of glucose import • extrinsic apoptotic signaling pathway in absence of ligand • cell cycle • cell population proliferation • GO:0072468 signal transduction • GO:1901047 insulin receptor signaling pathway • regulation of protein localization to plasma membrane • transforming growth factor beta receptor signaling pathway • regulation of fibroblast migration • signaling • adiponectin-activated signaling pathway • regulation of toll-like receptor 4 signaling pathway • cellular response to hepatocyte growth factor stimulus • regulation of innate immune response • positive regulation of glucose import • positive regulation of melanin biosynthetic process • positive regulation of cytokine production involved in inflammatory response • positive regulation of macropinocytosis • negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis • protein import into nucleus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26060	n/a
Ensembl	ENSG00000157500	n/a
UniProt	Q9UKG1	n/a
RefSeq (mRNA)	NM_012096	n/a
RefSeq (protein)	NP_036228	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APPL1 yw APPL1 a elwir hefyd yn Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APPL1.

• APPL
• MODY14
• DIP13alpha

Llyfryddiaeth

• "Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study. ". Brain Res. 2013. PMID 23246927.
• "The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration. ". Mol Biol Cell. 2012. PMID 22379109.
• "APPL1-Mediating Leptin Signaling Contributes to Proliferation and Migration of Cancer Cells. ". PLoS One. 2016. PMID 27820851.
• "Association of APPL1 Gene Polymorphism with Non-Alcoholic Fatty Liver Disease Susceptibility in a Chinese Han Population. ". Clin Lab. 2015. PMID 26731990.
• "APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.". J Cell Biol. 2015. PMID 26459602.