APOA1

APOA1
Strwythurau PDB Orthologau:PDBe RCSB Rhestr o ddynodwyr PDB 1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3K2S, 3R2P, 2MSC, 2MSD, 2MSE, 4V6M
Dynodwyr
Cyfenwau	APOA1, entrez:335, apo(a), apolipoprotein A1, Apolipoprotein A-I
Dynodwyr allanol	OMIM: 107680 MGI: 88049 HomoloGene: 47900 GeneCards: APOA1
Lleoliad y genyn (llygoedn) Cr. Cromosom 9 (llygoden) Band 9 A5.2|9 25.36 cM Start 46,228,580 bp End 46,230,466 bp
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lipase inhibitor activity • phosphatidylcholine binding • apolipoprotein receptor binding • high-density lipoprotein particle receptor binding • lipoprotein particle binding • phosphatidylcholine-sterol O-acyltransferase activator activity • phospholipid binding • apolipoprotein A-I receptor binding • enzyme binding • cholesterol transporter activity • amyloid-beta binding • phospholipid transporter activity • protein binding • chemorepellent activity • lipid transporter activity • cholesterol binding • identical protein binding • high-density lipoprotein particle binding • lipid binding • heat shock protein binding • receptor binding Cydrannau o'r gell • cytosol • endoplasmic reticulum lumen • chylomicron • extracellular region • cnewyllyn cell • extracellular vesicle • endocytic vesicle lumen • discoidal high-density lipoprotein particle • very-low-density lipoprotein particle • cell surface • secretory granule lumen • extracellular exosome • blood microparticle • endocytic vesicle • Cellbilen • spherical high-density lipoprotein particle • early endosome • high-density lipoprotein particle • cytoplasmic vesicle • extracellular space • low-density lipoprotein particle • intermediate-density lipoprotein particle • collagen-containing extracellular matrix Prosesau biolegol • positive regulation of Rho protein signal transduction • regulation of protein phosphorylation • cholesterol import • lipid transport • negative chemotaxis • positive regulation of cholesterol esterification • phospholipid efflux • phospholipid transport • negative regulation of hydrolase activity • receptor-mediated endocytosis • retinoid metabolic process • negative regulation of lipase activity • regulation of intestinal cholesterol absorption • negative regulation of cell adhesion molecule production • peripheral nervous system axon regeneration • endothelial cell proliferation • animal organ regeneration • peptidyl-methionine modification • cholesterol homeostasis • negative regulation of heterotypic cell-cell adhesion • transforming growth factor beta receptor signaling pathway • protein oxidation • negative regulation of inflammatory response • negative regulation of interleukin-1 beta secretion • phospholipid homeostasis • ERK1 and ERK2 cascade • negative regulation of cytokine secretion involved in immune response • positive regulation of fatty acid biosynthetic process • high-density lipoprotein particle clearance • lipoprotein metabolic process • G-protein coupled receptor signaling pathway • positive regulation of triglyceride catabolic process • response to nutrient • glucocorticoid metabolic process • lipid storage • protein stabilization • positive regulation of lipoprotein lipase activity • cholesterol metabolic process • response to estrogen • triglyceride catabolic process • transmembrane transport • transport • cholesterol efflux • integrin-mediated signaling pathway • phosphatidylcholine biosynthetic process • neuron projection regeneration • cellular protein metabolic process • negative regulation of very-low-density lipoprotein particle remodeling • steroid metabolic process • positive regulation of hydrolase activity • regulation of Cdc42 protein signal transduction • blood vessel endothelial cell migration • negative regulation of tumor necrosis factor-mediated signaling pathway • Lipid metabolism • cholesterol transport • platelet degranulation • adrenal gland development • high-density lipoprotein particle assembly • negative regulation of response to cytokine stimulus • high-density lipoprotein particle remodeling • positive regulation of substrate adhesion-dependent cell spreading • phospholipid metabolic process • vitamin transport • cholesterol biosynthetic process • response to drug • positive regulation of stress fiber assembly • triglyceride homeostasis • reverse cholesterol transport • lipoprotein biosynthetic process • positive regulation of cholesterol efflux • regulation of lipid metabolic process • regulation of cholesterol transport • chylomicron remodeling • very-low-density lipoprotein particle remodeling • chylomicron assembly • post-translational protein modification • positive regulation of lipid biosynthetic process • positive regulation of phagocytosis • positive regulation of phospholipid efflux Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	335	11806
Ensembl	ENSG00000118137	ENSMUSG00000032083
UniProt	P02647	Q00623
RefSeq (mRNA)	NM_000039 NM_001318017 NM_001318018 NM_001318021	NM_009692
RefSeq (protein)	NP_000030 NP_001304946 NP_001304947 NP_001304950 NP_000030.1 NP_001304946.1 NP_001304947.1	NP_033822
Lleoliad (UCSC)	n/a	Chr : 46.23 – 46.23 Mb
PubMed search
Wicidata
Gweld/Golygu Bod dynol Gweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn APOA1 yw APOA1 a elwir hefyd yn Apolipoprotein A-I, isoform CRA_a ac Apolipoprotein A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APOA1.

• apo(a)

Llyfryddiaeth

• "Low levels of ApoA1 improve risk prediction of type 2 diabetes mellitus. ". J Clin Lipidol. 2017. PMID 28502492.
• "Serum apoprotein A1 levels are inversely associated with disease activity in gout: From a southern Chinese Han population. ". Medicine (Baltimore). 2017. PMID 28445313.
• "Inflammatory markers modify the risk of recurrent coronary events associated with apolipoprotein A-I in postinfarction patients. ". J Clin Lipidol. 2017. PMID 28391888.
• "Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study. ". Lipids Health Dis. 2017. PMID 28372564.
• "In situ AFM imaging of apolipoprotein A-I directly derived from plasma HDL.". Atherosclerosis. 2017. PMID 28279834.