APBA1

APBA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AQC, 1U37, 1U38, 1U39, 1U3B, 1X11, 1X45, 1Y7N
Dynodwyr
Cyfenwau	APBA1, D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA, amyloid beta precursor protein binding family A member 1
Dynodwyr allanol	OMIM: 602414 HomoloGene: 897 GeneCards: APBA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • amyloid-beta binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • synaptic vesicle • perinuclear region of cytoplasm • cnewyllyn cell • neuron projection • Golgi apparatus • presynaptic active zone membrane • Schaffer collateral - CA1 synapse • glutamatergic synapse • Cellbilen • dendritic spine • synapse Prosesau biolegol • locomotory behavior • multicellular organism growth • axo-dendritic transport • in utero embryonic development • nervous system development • glutamate secretion • cell adhesion • regulation of gene expression • protein transport • intracellular protein transport • gamma-aminobutyric acid secretion • GO:0010554 neurotransmitter secretion • chemical synaptic transmission • GO:0034622 protein-containing complex assembly • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	320	n/a
Ensembl	ENSG00000107282 ENSG00000276497	n/a
UniProt	Q02410	n/a
RefSeq (mRNA)	NM_001163	n/a
RefSeq (protein)	NP_001154	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APBA1 yw APBA1 a elwir hefyd yn Amyloid beta precursor protein binding family A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q21.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APBA1.

• X11
• X11A
• LIN10
• MINT1
• D9S411E
• X11ALPHA

Llyfryddiaeth

• "Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein. ". J Neurochem. 2016. PMID 26865271.
• "The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. ". J Biol Chem. 2003. PMID 12970358.
• "Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. ". J Biol Chem. 2000. PMID 11010978.
• "Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. ". EMBO J. 1997. PMID 9321393.
• "NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.". J Biol Chem. 1990. PMID 1968060.