AP2M1

AP2M1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1H6E, 2JKT, 2JKR, 2VGL, 2BP5
Dynodwyr
Cyfenwau	AP2M1, AP50, CLAPM1, mu2, adaptor related protein complex 2 mu 1 subunit, adaptor related protein complex 2 subunit mu 1, MRD60
Dynodwyr allanol	OMIM: 601024 HomoloGene: 3000 GeneCards: AP2M1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• lipid binding; • clathrin adaptor activity; • transporter activity; • transmembrane transporter binding; • GO:0001948, GO:0016582 protein binding; • signal sequence binding; • low-density lipoprotein particle receptor binding;
Cydrannau o'r gell	• extracellular exosome; • lysosomal membrane; • AP-2 adaptor complex; • endocytic vesicle membrane; • cytosol; • bilen; • endolysosome membrane; • clathrin adaptor complex; • clathrin-coated pit; • clathrin-coated endocytic vesicle membrane; • Cellbilen; • clathrin-coated endocytic vesicle;
Prosesau biolegol	• ephrin receptor signaling pathway; • GO:0019049, GO:0030683 mitigation of host defenses by virus; • clathrin-dependent endocytosis; • negative regulation of protein localization to plasma membrane; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • endocytosis; • protein transport; • vesicle-mediated transport; • intracellular protein transport; • Wnt signaling pathway, planar cell polarity pathway; • microtubule-based movement; • membrane organization; • low-density lipoprotein particle receptor catabolic process; • low-density lipoprotein particle clearance; • GO:0015915 transport; • vesicle budding from membrane; • receptor internalization; • regulation of vesicle size;
	Sources:Amigo / QuickGO
Orthologau
	1173
	n/a
	ENSG00000161203
	n/a
	Q96CW1
	n/a
	NM_004068; NM_001025205; NM_001311198
	n/a
	NP_001020376; NP_001298127; NP_004059
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AP2M1 yw AP2M1 a elwir hefyd yn Adaptor related protein complex 2 mu 1 subunit ac AP-2 complex subunit mu (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q27.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AP2M1.

mu2
AP50
CLAPM1

Llyfryddiaeth

"Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly. ". PLoS Pathog. 2012. PMID 22916011.
"Roles of AP-2 in clathrin-mediated endocytosis. ". PLoS One. 2010. PMID 20485680.
"Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. ". Mol Biol Cell. 2007. PMID 17108328.
"Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. ". Proc Natl Acad Sci U S A. 2005. PMID 15911768.
"Endocytic clathrin-coated pit formation is independent of receptor internalization signal levels.". Mol Biol Cell. 1998. PMID 9571248.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AP2M1 - Cronfa NCBI

[1]

[2]