ANXA6

ANXA6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M9I
Dynodwyr
Cyfenwau	ANXA6, ANX6, CBP68, annexin A6, CPB-II, p70, p68
Dynodwyr allanol	OMIM: 114070 HomoloGene: 55558 GeneCards: ANXA6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • protein homodimerization activity • GTP binding • calcium-dependent protein binding • cholesterol binding • GO:0001948, GO:0016582 protein binding • ligand-gated ion channel activity • calcium-dependent phospholipid binding • lipid binding • phosphatidylserine binding • calcium channel activity • heparin binding • enzyme binding • chondroitin sulfate binding • signaling receptor activity • GO:0032403 protein-containing complex binding • actin filament binding Cydrannau o'r gell • cytoplasm • bilen • late endosome membrane • focal adhesion • melanosome • lysosomal membrane • mitocondria • perinuclear region of cytoplasm • extracellular exosome • collagen-containing extracellular matrix Prosesau biolegol • regulation of muscle contraction • mitochondrial calcium ion homeostasis • cludo transmembrane rhwng ïonau • apoptotic signaling pathway • protein homooligomerization • calcium ion transport • neural crest cell migration • plasma membrane repair • growth plate cartilage chondrocyte differentiation • biomineral tissue development • negative regulation of sequestering of calcium ion • calcium ion import • calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	309	n/a
Ensembl	ENSG00000197043	n/a
UniProt	P08133	n/a
RefSeq (mRNA)	NM_001155 NM_001193544 NM_004033 NM_001363114	n/a
RefSeq (protein)	NP_001146 NP_001180473 NP_001350043	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ANXA6 yw ANXA6 a elwir hefyd yn Annexin A6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ANXA6.

• ANX6
• CBP68

Llyfryddiaeth

• "A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer. ". Br J Cancer. 2017. PMID 28881357.
• "Two translation initiation codons direct the expression of annexin VI 64kDa and 68kDa isoforms. ". Mol Genet Metab. 2016. PMID 27743858.
• "Annexin A6 protein is downregulated in human hepatocellular carcinoma. ". Mol Cell Biochem. 2016. PMID 27334756.
• "Gene-based meta-analysis of genome-wide association study data identifies independent single-nucleotide polymorphisms in ANXA6 as being associated with systemic lupus erythematosus in Asian populations. ". Arthritis Rheumatol. 2015. PMID 26202167.
• "Annexin A6-balanced late endosomal cholesterol controls influenza A replication and propagation.". MBio. 2013. PMID 24194536.