ALOX12

ALOX12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3D3L
Dynodwyr
Cyfenwau	ALOX12, 12-LOX, 12S-LOX, LOG12, arachidonate 12-lipoxygenase, 12S type
Dynodwyr allanol	OMIM: 152391 HomoloGene: 560 GeneCards: ALOX12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hepoxilin A3 synthase activity • iron ion binding • arachidonate 12(S)-lipoxygenase activity • dioxygenase activity • hepoxilin-epoxide hydrolase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • linoleate 13S-lipoxygenase activity • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • hydrolase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • sarcolemma • extracellular exosome Prosesau biolegol • linoleic acid metabolic process • positive regulation of cell death • positive regulation of endothelial cell differentiation • establishment of skin barrier • lipoxin A4 biosynthetic process • lipid metabolism • positive regulation of cell migration • lipoxin B4 biosynthetic process • GO:0010260 heneiddio • negative regulation of apoptotic process • negative regulation of platelet aggregation • negative regulation of muscle cell apoptotic process • fatty acid metabolic process • positive regulation of angiogenesis • reactive oxygen species metabolic process • superoxide anion generation • positive regulation of endothelial cell migration • lipoxygenase pathway • hepoxilin biosynthetic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of cell growth • GO:1901313 positive regulation of gene expression • leukotriene A4 metabolic process • positive regulation of mitochondrial depolarization • fatty acid oxidation • positive regulation of cell population proliferation • positive regulation of apoptotic process • cellular response to lipid • hepoxilin metabolic process • lipoxin metabolic process • positive regulation of cell adhesion • positive regulation of smooth muscle cell proliferation • arachidonic acid metabolic process • long-chain fatty acid biosynthetic process • positive regulation of blood vessel endothelial cell migration • positive regulation of endothelial tube morphogenesis • lipoxin biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	239	n/a
Ensembl	ENSG00000108839	n/a
UniProt	P18054	n/a
RefSeq (mRNA)	NM_000697	n/a
RefSeq (protein)	NP_000688	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ALOX12 yw ALOX12 a elwir hefyd yn Arachidonate 12-lipoxygenase, 12S type (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ALOX12.

• LOG12
• 12-LOX
• 12S-LOX

Llyfryddiaeth

• "A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex. ". Psychoneuroendocrinology. 2015. PMID 26372769.
• "Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. ". J Clin Endocrinol Metab. 2015. PMID 25532042.
• "Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study. ". Mol Carcinog. 2015. PMID 25339205.
• "[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo]. ". Magy Onkol. 2014. PMID 25260086.
• "ALOX12 in human toxoplasmosis.". Infect Immun. 2014. PMID 24686056.