ALAD

ALAD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E51, 1PV8, 5HNR, 5HMS
Dynodwyr
Cyfenwau	ALAD, ALADH, PBGS, aminolevulinate dehydratase, ALA dehydratase
Dynodwyr allanol	OMIM: 125270 HomoloGene: 16 GeneCards: ALAD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • porphobilinogen synthase activity • zinc ion binding • metal ion binding • catalytic activity • lyase activity • identical protein binding • proteasome core complex binding Cydrannau o'r gell • cytosol • extracellular exosome • cnewyllyn cell • extracellular region • extracellular space • secretory granule lumen • ficolin-1-rich granule lumen • proteasome core complex Prosesau biolegol • cellular response to interleukin-4 • response to ionizing radiation • response to platinum ion • response to selenium ion • response to amino acid • cellular response to lead ion • response to hypoxia • response to cadmium ion • response to fatty acid • response to vitamin B1 • GO:1904578 response to organic cyclic compound • response to vitamin • response to nutrient • response to metal ion • response to zinc ion • response to glucocorticoid • response to arsenic-containing substance • protoporphyrinogen IX biosynthetic process • GO:0001306 response to oxidative stress • response to organic substance • response to activity • tetrapyrrole biosynthetic process • porphyrin-containing compound biosynthetic process • response to vitamin E • response to iron ion • heme biosynthetic process • response to lipopolysaccharide • response to nutrient levels • response to lead ion • response to inorganic substance • response to aluminum ion • response to hormone • response to mercury ion • metabolaeth • response to methylmercury • response to ethanol • response to cobalt ion • protein homooligomerization • response to toxic substance • response to herbicide • neutrophil degranulation • negative regulation of proteasomal protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	210	n/a
Ensembl	ENSG00000148218	n/a
UniProt	P13716	n/a
RefSeq (mRNA)	NM_000031 NM_001003945 NM_001317745	n/a
RefSeq (protein)	NP_000022 NP_001003945 NP_001304674	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ALAD yw ALAD a elwir hefyd yn Aminolevulinate dehydratase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ALAD.

• PBGS
• ALADH

Llyfryddiaeth

• "Downregulation of delta-aminolevulinate dehydratase is associated with poor prognosis in patients with breast cancer. ". Cancer Sci. 2017. PMID 28403546.
• "Delta-aminolevulinate dehydratase activity and oxidative stress markers in preeclampsia. ". Biomed Pharmacother. 2016. PMID 27657831.
• "Association between delta-aminolevulinic acid dehydratase polymorphism and placental lead levels. ". Environ Toxicol Pharmacol. 2016. PMID 26701682.
• "Relationship among maternal blood lead, ALAD gene polymorphism and neonatal neurobehavioral development. ". Int J Clin Exp Pathol. 2015. PMID 26261627.
• "Genome-wide association study of blood lead shows multiple associations near ALAD.". Hum Mol Genet. 2015. PMID 25820613.