AKT2

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AKT2
Protein AKT2 PDB 1gzk.png
Strwythurau
PDBOrthologau:PDBe RCSB
Dynodwyr
CyfenwauAKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
Dynodwyr allanolOMIM: 164731 MGI: 104874 HomoloGene: 48773 GeneCards: AKT2
Patrwm RNA pattern
PBB GE AKT2 211453 s at fs.png

PBB GE AKT2 203809 s at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243027
NM_001243028
NM_001626
NM_001330511

NM_001110208
NM_007434
NM_001331108
NM_001331109

RefSeq (protein)

NP_001229956
NP_001229957
NP_001317440
NP_001617

NP_001103678
NP_001318037
NP_001318038
NP_031460

Lleoliad (UCSC)n/aChr : 27.59 – 27.64 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKT2 yw AKT2 a elwir hefyd yn RAC-beta serine/threonine-protein kinase ac AKT serine/threonine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKT2.

  • PKBB
  • PRKBB
  • HIHGHH
  • PKBBETA
  • RAC-BETA

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia. ". J Clin Endocrinol Metab. 2017. PMID 28541532.
  • "A Low-Frequency Inactivating AKT2Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. ". Diabetes. 2017. PMID 28341696.
  • "A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain. ". PLoS One. 2016. PMID 28036396.
  • "Hypermethylation of AKT2 gene is associated with neural-tube defects in fetus. ". Placenta. 2016. PMID 27871477.
  • "Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation.". Sci Rep. 2015. PMID 26234648.

Cyfeiriadau[golygu | golygu cod y dudalen]

  1. 1.0 1.1 1.2 GRCm38: Ensembl release 89: ENSMUSG00000004056 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. AKT2 - Cronfa NCBI