AKR7A2

AKR7A2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BP1
Dynodwyr
Cyfenwau	AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7, aldo-keto reductase family 7, member A2, aldo-keto reductase family 7 member A2
Dynodwyr allanol	OMIM: 603418 HomoloGene: 2737 GeneCards: AKR7A2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • alditol:NADP+ 1-oxidoreductase activity • electron transfer activity • oxidoreductase activity • phenanthrene-9,10-epoxide hydrolase activity • aldo-keto reductase (NADP) activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • Golgi apparatus • extracellular exosome • cytosol Prosesau biolegol • xenobiotic metabolic process • cellular aldehyde metabolic process • daunorubicin metabolic process • doxorubicin metabolic process • carbohydrate metabolic process • electron transport chain Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8574	n/a
Ensembl	ENSG00000053371	n/a
UniProt	O43488	n/a
RefSeq (mRNA)	NM_003689 NM_001320979	n/a
RefSeq (protein)	NP_001307908 NP_003680	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR7A2 yw AKR7A2 a elwir hefyd yn Aflatoxin B1 aldehyde reductase member 2 ac Aldo-keto reductase family 7 member A2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR7A2.

• AFAR
• AKR7
• AFAR1
• AFB1-AR1

Llyfryddiaeth

• "Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells. ". Cancer Res. 1998. PMID 9823300.
• "Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2. ". Chem Biol Interact. 2015. PMID 25451587.
• "The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner. ". Cell Mol Biol Lett. 2016. PMID 28536627.
• "Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. ". Cancer Lett. 2008. PMID 18752886.
• "Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2.". J Biol Chem. 2007. PMID 17591773.