AKR1C4

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AKR1C4
Protein AKR1C4 PDB 2fvl.png
Strwythurau
PDBOrthologau:PDBe RCSB
Dynodwyr
CyfenwauAKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1, member C4, aldo-keto reductase family 1 member C4
Dynodwyr allanolOMIM: 600451 MGI: 1933427 HomoloGene: 84695 GeneCards: AKR1C4
EC number1.1.1.225
Patrwm RNA pattern
PBB GE AKR1C4 210558 at fs.png

PBB GE AKR1C1 211653 x at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001818

NM_030611

RefSeq (protein)

NP_001809

NP_085114

Lleoliad (UCSC)n/aChr : 4.43 – 4.46 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1C4 yw AKR1C4 a elwir hefyd yn Aldo-keto reductase family 1 member C4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1C4.

  • C11
  • CDR
  • DD4
  • CHDR
  • DD-4
  • HAKRA
  • 3-alpha-HSD

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder. ". J Affect Disord. 2011. PMID 21570127.
  • "An estrogen metabolism-related polymorphism of the 17-alpha HSD gene is associated with perimenopausal body mass index. ". Fertil Steril. 2007. PMID 17207797.
  • "Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. ". Mol Psychiatry. 2006. PMID 16344854.
  • "Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha. ". Biochem J. 2001. PMID 11284743.
  • "Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.". J Clin Endocrinol Metab. 2001. PMID 11158055.

Cyfeiriadau[golygu | golygu cod y dudalen]

  1. 1.0 1.1 1.2 GRCm38: Ensembl release 89: ENSMUSG00000021210 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. AKR1C4 - Cronfa NCBI