AKR1C4

AKR1C4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FVL
Dynodwyr
Cyfenwau	AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1, member C4, aldo-keto reductase family 1 member C4
Dynodwyr allanol	OMIM: 600451 HomoloGene: 84695 GeneCards: AKR1C4
EC number	1.1.1.225
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • retinal dehydrogenase activity • aldo-keto reductase (NADP) activity • bile acid transmembrane transporter activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • chlordecone reductase activity • electron transfer activity • oxidoreductase activity • androsterone dehydrogenase activity • alditol:NADP+ 1-oxidoreductase activity • alcohol dehydrogenase (NADP+) activity • steroid dehydrogenase activity • ketosteroid monooxygenase activity Cydrannau o'r gell • cytoplasm • cytosol • extracellular exosome Prosesau biolegol • cellular response to jasmonic acid stimulus • steroid metabolic process • daunorubicin metabolic process • doxorubicin metabolic process • androgen metabolic process • retinoid metabolic process • bile acid and bile salt transport • bile acid biosynthetic process • electron transport chain • prostaglandin metabolic process • progesterone metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1109	n/a
Ensembl	ENSG00000198610	n/a
UniProt	P17516	n/a
RefSeq (mRNA)	NM_001818	n/a
RefSeq (protein)	NP_001809	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1C4 yw AKR1C4 a elwir hefyd yn Aldo-keto reductase family 1 member C4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1C4.

• C11
• CDR
• DD4
• CHDR
• DD-4
• HAKRA
• 3-alpha-HSD

Llyfryddiaeth

• "AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder. ". J Affect Disord. 2011. PMID 21570127.
• "An estrogen metabolism-related polymorphism of the 17-alpha HSD gene is associated with perimenopausal body mass index. ". Fertil Steril. 2007. PMID 17207797.
• "Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. ". Mol Psychiatry. 2006. PMID 16344854.
• "Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha. ". Biochem J. 2001. PMID 11284743.
• "Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.". J Clin Endocrinol Metab. 2001. PMID 11158055.