AKR1C1

AKR1C1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MRQ, 3C3U, 3GUG, 3NTY, 4YVP
Dynodwyr
Cyfenwau	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1 member C1
Dynodwyr allanol	OMIM: 600449 HomoloGene: 134114 GeneCards: AKR1C1
EC number	1.1.1.112
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity • alditol:NADP+ 1-oxidoreductase activity • indanol dehydrogenase activity • aldo-keto reductase (NADP) activity • 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity • androsterone dehydrogenase (B-specific) activity • phenanthrene 9,10-monooxygenase activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • bile acid binding • GO:0001948, GO:0016582 protein binding • carboxylic acid binding • oxidoreductase activity • ketosteroid monooxygenase activity • alcohol dehydrogenase (NADP+) activity • steroid dehydrogenase activity Cydrannau o'r gell • cytoplasm • cytosol • extracellular exosome Prosesau biolegol • cellular response to jasmonic acid stimulus • epithelial cell differentiation • daunorubicin metabolic process • doxorubicin metabolic process • progesterone metabolic process • bile acid metabolic process • Treulio bwyd • retinal metabolic process • retinoid metabolic process • response to organophosphorus • bile acid and bile salt transport • intestinal cholesterol absorption • xenobiotic metabolic process • cholesterol homeostasis • protein homooligomerization • steroid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1645	n/a
Ensembl	ENSG00000187134	n/a
UniProt	Q04828	n/a
RefSeq (mRNA)	NM_001353	n/a
RefSeq (protein)	NP_001344	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1C1 yw AKR1C1 a elwir hefyd yn Aldo-keto reductase family 1 member C1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1C1.

• C9
• DD1
• DDH
• DDH1
• H-37
• HBAB
• MBAB
• HAKRC
• DD1/DD2
• 2-ALPHA-HSD
• 20-ALPHA-HSD

Llyfryddiaeth

• "Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?". Depress Anxiety. 2014. PMID 24390875.
• "Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe. ". J Biotechnol. 2010. PMID 20727920.
• "Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors. ". Biochim Biophys Acta. 2010. PMID 20673851.
• "Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells. ". Carcinogenesis. 2009. PMID 19696165.
• "Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.". J Biol Chem. 2009. PMID 19218247.