AKR1C1

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AKR1C1
Protein AKR1C1 PDB 1ihi.png
Strwythurau
PDBOrthologau:PDBe RCSB
Dynodwyr
CyfenwauAKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1 member C1
Dynodwyr allanolOMIM: 600449 MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C1
EC number1.1.1.112
Patrwm RNA pattern
PBB GE AKR1C1 204151 x at fs.png

PBB GE AKR1C1 209699 x at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001353

NM_029901

RefSeq (protein)

NP_001344

NP_084177

Lleoliad (UCSC)n/aChr : 4.57 – 4.59 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1C1 yw AKR1C1 a elwir hefyd yn Aldo-keto reductase family 1 member C1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1C1.

  • C9
  • DD1
  • DDH
  • DDH1
  • H-37
  • HBAB
  • MBAB
  • HAKRC
  • DD1/DD2
  • 2-ALPHA-HSD
  • 20-ALPHA-HSD

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?". Depress Anxiety. 2014. PMID 24390875.
  • "Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe. ". J Biotechnol. 2010. PMID 20727920.
  • "Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors. ". Biochim Biophys Acta. 2010. PMID 20673851.
  • "Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells. ". Carcinogenesis. 2009. PMID 19696165.
  • "Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.". J Biol Chem. 2009. PMID 19218247.

Cyfeiriadau[golygu | golygu cod y dudalen]