AIFM1

AIFM1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M6I, 4BUR, 4BV6, 4FDC, 4LII, 5FS7, 5FS9, 5FS6, 5FS8
Dynodwyr
Cyfenwau	AIFM1, AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, DFNX5, apoptosis inducing factor, mitochondria associated 1, apoptosis inducing factor mitochondria associated 1, AUNX1, SEMDHL
Dynodwyr allanol	OMIM: 300169 HomoloGene: 3100 GeneCards: AIFM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein dimerization activity • oxidoreductase activity • flavin adenine dinucleotide binding • NAD(P)H oxidase H2O2-forming activity • FAD binding • oxidoreductase activity, acting on NAD(P)H • DNA binding Cydrannau o'r gell • mitochondrial inner membrane • cytoplasm • cytosol • bilen • perinuclear region of cytoplasm • mitochondrial intermembrane space • mitocondria • cnewyllyn cell Prosesau biolegol • neuron apoptotic process • response to ischemia • chromosome condensation • cellular response to oxygen-glucose deprivation • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of neuron apoptotic process • regulation of apoptotic DNA fragmentation • cellular response to hydrogen peroxide • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • positive regulation of apoptotic process • cellular response to nitric oxide • response to L-glutamate • positive regulation of cell death • mitochondrial respiratory chain complex I assembly • response to toxic substance • cellular response to estradiol stimulus • neuron differentiation • cellular response to aldosterone • GO:0097285 apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9131	n/a
Ensembl	ENSG00000156709	n/a
UniProt	O95831	n/a
RefSeq (mRNA)	NM_001130846 NM_001130847 NM_004208 NM_145812 NM_145813	n/a
RefSeq (protein)	NP_001124318 NP_001124319 NP_004199 NP_665811	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AIFM1 yw AIFM1 a elwir hefyd yn Apoptosis inducing factor mitochondria associated 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AIFM1.

• AIF
• CMT2D
• CMTX4
• COWCK
• DFNX5
• NADMR
• NAMSD
• PDCD8
• COXPD6

Llyfryddiaeth

• "Structure/Function Relations in AIFM1 Variants Associated with Neurodegenerative Disorders. ". J Mol Biol. 2016. PMID 27178839.
• "Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells. ". BMC Cancer. 2016. PMID 27108222.
• "Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation. ". Arch Virol. 2017. PMID 27853862.
• "Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. ". Structure. 2016. PMID 27818101.
• "The role of apoptosis inducing factor in the apoptosis of retinal pigment epithelium cells induced by oxidative stress.". Cell Mol Biol (Noisy-le-grand). 2016. PMID 27453270.