ADCYAP1

ADCYAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GEA, 2D2P, 2JOD
Dynodwyr
Cyfenwau	ADCYAP1, PACAP, adenylate cyclase activating polypeptide 1
Dynodwyr allanol	OMIM: 102980 HomoloGene: 869 GeneCards: ADCYAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • pituitary adenylate cyclase activating polypeptide activity • hormone activity • peptide hormone receptor binding • GO:0001948, GO:0016582 protein binding • pituitary adenylate cyclase-activating polypeptide receptor binding • neuropeptide hormone activity • signaling receptor binding Cydrannau o'r gell • intracellular anatomical structure • extracellular region • terminal bouton • extracellular space • neuron projection • perikaryon • cell body fiber Prosesau biolegol • histamine secretion • pituitary gland development • regulation of G protein-coupled receptor signaling pathway • negative regulation of glial cell proliferation • female pregnancy • cell-cell signaling • negative regulation of cell cycle • negative regulation of muscle cell apoptotic process • behavioral fear response • nervous system development • activation of adenylate cyclase activity • regulation of protein localization • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • ATP metabolic process • negative regulation of acute inflammatory response to non-antigenic stimulus • regulation of oligodendrocyte progenitor proliferation • cellular response to glucocorticoid stimulus • GO:1901313 positive regulation of gene expression • GO:0034259 negative regulation of GTPase activity • positive regulation of synaptic transmission, glutamatergic • positive regulation of chemokine (C-C motif) ligand 5 production • regulation of postsynaptic membrane potential • positive regulation of cell population proliferation • negative regulation of potassium ion transport • positive regulation of ERK1 and ERK2 cascade • positive regulation of interleukin-6 production • positive regulation of neuron projection development • response to starvation • ovarian follicle development • sensory perception of pain • response to ethanol • negative regulation of acute inflammatory response to antigenic stimulus • neuropeptide signaling pathway • neuron projection development • cAMP-mediated signaling • positive regulation of somatostatin secretion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein kinase activity • regulation of protein phosphorylation • positive regulation of cytosolic calcium ion concentration • insulin secretion • positive regulation of growth hormone secretion • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cAMP-mediated signaling • brain development • camera-type eye development • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	116	n/a
Ensembl	ENSG00000141433	n/a
UniProt	P18509	n/a
RefSeq (mRNA)	NM_001099733 NM_001117	n/a
RefSeq (protein)	NP_001093203 NP_001108	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADCYAP1 yw ADCYAP1 a elwir hefyd yn Adenylate cyclase activating polypeptide 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18p11.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADCYAP1.

• PACAP

Llyfryddiaeth

• "A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants. ". J Headache Pain. 2016. PMID 27957625.
• "No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine. ". Headache. 2016. PMID 27634731.
• "Release of PACAP-38 in episodic cluster headache patients - an exploratory study. ". J Headache Pain. 2016. PMID 27475101.
• "Pleiotropic and retinoprotective functions of PACAP. ". Anat Sci Int. 2016. PMID 27324639.
• "Interictal plasma pituitary adenylate cyclase-activating polypeptide levels are decreased in migraineurs but remain unchanged in patients with tension-type headache.". Clin Chim Acta. 2015. PMID 26296898.