ADARB1

ADARB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZY7, 5ED1, 5ED2, 5HP3, 5HP2
Dynodwyr
Cyfenwau	ADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1, adenosine deaminase RNA specific B1, NEDHYMS
Dynodwyr allanol	OMIM: 601218 HomoloGene: 8280 GeneCards: ADARB1
EC number	3.5.4.37
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • adenosine deaminase activity • GO:0001948, GO:0016582 protein binding • RNA binding • double-stranded RNA binding • mRNA binding • hydrolase activity • double-stranded RNA adenosine deaminase activity • tRNA-specific adenosine deaminase activity Cydrannau o'r gell • nucleoplasm • nucleolus • cnewyllyn cell • cytosol • cytoplasm Prosesau biolegol • GO:0033168, GO:0036404, GO:1902360 RNA processing • immune system process • mRNA processing • base conversion or substitution editing • regulation of cell cycle • negative regulation of cell migration • defense response to virus • negative regulation of protein kinase activity by regulation of protein phosphorylation • positive regulation of viral genome replication • innate immune response • adenosine to inosine editing • negative regulation of cell population proliferation • neuromuscular synaptic transmission • facial nerve morphogenesis • hypoglossal nerve morphogenesis • spinal cord ventral commissure morphogenesis • multicellular organism growth • neuromuscular process controlling posture • innervation • muscle tissue morphogenesis • motor behavior • motor neuron apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	104	n/a
Ensembl	ENSG00000197381	n/a
UniProt	P78563	n/a
RefSeq (mRNA)	NM_001033049 NM_001112 NM_001160230 NM_015833 NM_015834 NM_001346687 NM_001346688	n/a
RefSeq (protein)	NP_001103 NP_001153702 NP_001333616 NP_001333617 NP_056648 NP_056649	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADARB1 yw ADARB1 a elwir hefyd yn Adenosine deaminase, RNA specific B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADARB1.

• RED1
• ADAR2
• DRABA2
• DRADA2

Llyfryddiaeth

• "Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. ". Nucleic Acids Res. 2016. PMID 27614075.
• "Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. ". Nat Struct Mol Biol. 2016. PMID 27065196.
• "Effect of mismatch on binding of ADAR2/GluR-2 pre-mRNA complex. ". J Mol Model. 2015. PMID 26252972.
• "Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma. ". Oncol Rep. 2015. PMID 25873329.
• "Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2.". Nucleic Acids Res. 2015. PMID 25564529.