ADAR

ADAR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QBJ, 1QGP, 1XMK, 2ACJ, 2GXB, 2L54, 2MDR, 3F21, 3F22, 3F23, 3IRQ, 3IRR
Dynodwyr
Cyfenwau	ADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD
Dynodwyr allanol	OMIM: 146920 HomoloGene: 9281 GeneCards: ADAR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • metal ion binding • double-stranded RNA adenosine deaminase activity • adenosine deaminase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • RNA binding • double-stranded RNA binding • tRNA-specific adenosine deaminase activity Cydrannau o'r gell • cytoplasm • bilen • supraspliceosomal complex • nucleoplasm • nucleolus • cnewyllyn cell Prosesau biolegol • hematopoietic stem cell homeostasis • cellular response to virus • GO:0033168, GO:0036404, GO:1902360 RNA processing • protein import into nucleus • immune system process • negative regulation of type I interferon-mediated signaling pathway • mRNA processing • response to virus • base conversion or substitution editing • negative regulation of apoptotic process • in utero embryonic development • pre-miRNA processing • negative regulation of viral genome replication • defense response to virus • type I interferon signaling pathway • osteoblast differentiation • hematopoietic progenitor cell differentiation • protein export from nucleus • response to interferon-alpha • negative regulation of protein kinase activity by regulation of protein phosphorylation • erythrocyte differentiation • somatic diversification of immune receptors via somatic mutation • definitive hemopoiesis • positive regulation of viral genome replication • negative regulation of RNA interference • gene silencing • innate immune response • adenosine to inosine editing • production of miRNAs involved in gene silencing by miRNA Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	103	n/a
Ensembl	ENSG00000160710	n/a
UniProt	P55265	n/a
RefSeq (mRNA)	NM_001025107 NM_001111 NM_001193495 NM_015840 NM_015841 NM_001365045 NM_001365046 NM_001365047 NM_001365048 NM_001365049	n/a
RefSeq (protein)	NP_001020278 NP_001102 NP_001180424 NP_056655 NP_056656	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAR yw ADAR a elwir hefyd yn Double-stranded RNA-specific adenosine deaminase ac Adenosine deaminase, RNA specific (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAR.

• DSH
• AGS6
• G1P1
• IFI4
• P136
• ADAR1
• DRADA
• DSRAD
• IFI-4
• K88DSRBP

Llyfryddiaeth

• "ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer. ". Tumour Biol. 2017. PMID 29022489.
• "RNA editing is induced by type I interferon in esophageal squamous cell carcinoma. ". Tumour Biol. 2017. PMID 28714361.
• "Assessing the potential function of ADAR1 in virus-associated sepsis. ". Front Biosci (Landmark Ed). 2017. PMID 28199207.
• "ADAR1 overexpression is associated with cervical cancer progression and angiogenesis. ". Diagn Pathol. 2017. PMID 28109322.
• "Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases.". Genes (Basel). 2016. PMID 27999332.